Cafestol analogues from : inhibition and molecular docking to -glucosidase.

A new cafestol-type diterpenoid, 5-hydroxy-2-oxocafestol named coffecanepholide C () along with three known diterpenoids including cafestol , tricalysiolide A () and atractyligenin () were identified from the trunks collected at Lam Dong province, Vietnam. Their structures were elucidated by HRESIMS and NMR spectroscopic analysis (H, C, COSY, HSQC, HMBC, and NOESY NMR) as well as compared with data in the literature. Upon evaluation of the -glucosidase inhibitory activity, compound (IC = 142.