Manufacturing exosomes for wound healing: Comparative analysis of culture media.

Mesenchymal stem cell (MSC)-derived exosomes (EXs) have emerged as promising therapeutic agents for wound healing. However, the optimal conditions for manufacturing MSC-derived EXs that maximize their wound-healing potential have yet to be established. Hence, we compared the efficacy of five different MSC culture media, including three different serum-free, a platelet-supplemented, and a fetal bovine serum-supplemented media, in exosome manufacturing for wound healing applications.

Synthesis, Biological Evaluation, and Molecular Modeling Studies of 1-Aryl-1-pyrazole-Fused Curcumin Analogues as Anticancer Agents.

Addressing the growing burden of cancer and the shortcomings of chemotherapy in cancer treatment are the current research goals. Research to overcome the limitations of curcumin and to improve its anticancer activity via its heterocycle-fused monocarbonyl analogues (MACs) has immense potential. In this study, 32 asymmetric MACs fused with 1-aryl-1-pyrazole () were synthesized and characterized to develop new curcumin analogues.

Simple and Economical Process for Producing Amantadine Hydrochloride.

A simple and economical process for producing amantadine hydrochloride () on a 250 g scale, an antiviral and anti-Parkinson drug, has been developed. Several methods for the preparation of through intermediate -(1-adamantyl)-acetamide () in four or three steps were reported. These procedures started with adamantine () or 1-bromoadamantane (), acetonitrile, and sulfuric acid by using the Ritter-type reaction to obtain -(1-adamantyl)-acetamide, which was deacetylated to afford 1-amino-adamantane () and then the salt formed with anhydrous HCl gives with the overall yield of being 50-58%.

Correction to "Simple Two-step Procedure for the Synthesis of Memantine Hydrochloride from 1,3-Dimethyl-adamantane".

[This corrects the article DOI: 10.1021/acsomega.0c01589.

Simple Two-step Procedure for the Synthesis of Memantine Hydrochloride from 1,3-Dimethyl-adamantane.

Memantine hydrochloride is a medicine used for the treatment of Alzheimer's disease. A number of methods for the preparation of memantine hydrochloride have been reported. These procedures started from 1,3-dimethyl-adamantane by as many as using three or four reaction steps to produce memantine hydrochloride with overall yields ranging from 54 to 77%.

(4)-Morpholinothiosemicarbazide-Modified Cellulose: Synthesis, Structure, Kinetics, Thermodynamics, and Ni(II) Removal Studies.

In this study, cellulose extracted from straw was modified using (4)-morpholinothiosemicarbazide to generate a novel adsorbent as a chelate-complex-based material. The effects of pH, time, temperature, and mass ratios of KIO: cellulose on the yield of the oxidation were analyzed using iodometric titration and photometric methods. The accuracy and precision of the above two methods were evaluated using Student and Fisher statistical distribution.

Synthesis and Bioactivity of Thiosemicarbazones Containing Adamantane Skeletons.

Reaction of 4-(1-adamantyl)-3-thiosemicarbazide () with numerous substituted acetophenones and benzaldehydes yielded the corresponding thiosemicarbazones containing adamantane skeletons. The synthesized compounds were evaluated for their in vitro activities against some Gram-positive and Gram-negative bacteria, and the fungus , and cytotoxicity against four cancer cell lines (Hep3B, HeLa, A549, and MCF-7). All of them showed good antifungal activity against .

Synthesis and Bioactivity of Hydrazide-Hydrazones with the 1-Adamantyl-Carbonyl Moiety.

Reaction of 1-adamantyl carbohydrazide () with various substituted benzaldehydes and acetophenones yielded the corresponding hydrazide-hydrazones with a 1-adamantane carbonyl moiety. The new synthesized compounds were tested for activities against some Gram-negative and Gram-positive bacteria, and the fungus . Compounds , , , and displayed potential antibacterial activity against tested Gram-positive bacteria and , while compounds and possessed cytotoxicity against tested human cancer cell lines.

A new flavan-3-ol and the anti-inflammatory effect of flavonoids from the fruit peels of Wisteria floribunda.

A new flavan-3-ol, (+)-afzelechin 5-O-β-d-glucopyranoside (2), together with 13 known flavonoids (1, 3-14), was isolated from the fruit peels of Wisteria floribunda. Their structures were assigned by detailed interpretation of NMR, MS, and CD spectroscopic data, as well as by comparing with published reports. The in vitro anti-inflammatory activity of the isolated compounds (1-14) was examined.