Macrophage blockade using nature-inspired ferrihydrite for enhanced nanoparticle delivery to tumor.

The rapid elimination of systemically administered drug nanocarriers by the mononuclear phagocyte system (MPS) compromises nanomedicine delivery efficacy. To mitigate this problem, an approach to block the MPS has been introduced and implemented by intravenous pre-administering blocker nanoparticles. The required large doses of blocker nanoparticles appeared to burden the MPS, raising toxicity concerns.

A comparative Raman study between PrMnO , NdMnO , TbMnO and DyMnO .

In this paper, we present a detailed Raman study of the non-multiferroic compounds PrMnO and NdMnO and the multiferroic compounds TbMnO and DyMnO as a function of temperature and magnetic field. All studied systems show anomalous phonon shifts close to the Néel transition T . In PrMnO and NdMnO , the frequency softenings are partly attributed to an orbital-spin-phonon coupling whereas in TbMnO and DyMnO , the relatively weak frequency shifts are rather attributed to an expansion of the Mn-O bond lengths.