Biphasic reaction after inhalation of Haemophilus influenzae in patients with chronic nonspecific lung disease.

In patients with chronic nonspecific lung disease (CNSLD), who had precipitins against Haemophilus influenzae (HI), a biphasic bronchial obstructive reaction is described after inhalation of killed HI bacteria. There was an early obstructive reaction, occurring immediately after the inhalation and lasting for 1 hr, followed by a late reaction, which started 5-6 hr after the inhalation and lasted for about 8 hr. The late reaction was accompanied by fever, malaise and leucocytosis.

Exercise-induced airway obstruction in relation to chronic obstructive lung disease.

16-20. Forty-two patients with chronic obstructive lung disease and clinically suspected exercise-induced airway obstruction were studied to ascertain whether those with proven exercise-induced airway obstruction had specific distinguishing features. Exercise-induced airway obstruction (defined as a fall of FEV of at least 10% of the pre-exercise values) was detected in 20 of the 42 patients.