[The role of yearbook "The significant and anniversary dates of history of medicine" in training of historians of medicine].

The N.A. Semashko national research institute of public health during 57 years published collections "The significant and anniversary dates of history of medicine" reflecting main dates of universal and national medicine.

[Experience with selenium used to recover adrenocortical function in patients taking glucocorticosteroids long].

Aim: To study the effect of selenium on adrenocortical function in patients taking glucocorticosteroids (GCS) long.

Subjects And Methods: The study included 56 patients who had been long taking oral GCS for the underlying disease. Adrenocortical function was evaluated by a short synacthen test; adrenal insufficiency (mean cortisol level 8.

[The role of medical community in Russian national medicine].

The article deals with the history of becoming and development of medical societies in prerevolutionary Russia. Their input into development of national science, of actual issues of public health, into consolidation of medical community and practical curative and sanitary activities is demonstrated.

[MRI-parameters of frontal lobes in schizophrenia: correlations with the level of autoantibodies to nerve growth factor in the blood serum].

The relationship between MRI-parameters of frontal lobes and levels of autoantibodies to nerve growth factor (Aab-NGF) in the blood serum of patients with schizophrenia and their relatives was studied. The negative correlation between the Aab-NGF level and the total volume of frontal lobes (r= -0,59; p<0,01) was found in the group of patients. No significant correlations were found in the control groups of healthy subjects without family history of schizophrenia and relatives of patients.

[Relation between immunological and neurophysiologic markers during exacerbation of schizophrenic process].

Relation between leukocyte elastase (LE) activity of peripheral blood and temporal parameters of late cognitive component of event-related potentials (ERP) was studied in 36 patients with different types of schizophrenia and 28 healthy controls. Both P300 latency and amplitude correlated with LE activity in patients, but not in controls. The results suggest a relationship between innate immunity activation and pathophysiologic processes underlying cognitive impairment in schizophrenia.

[Peculiarities of attention in families with schizophrenia: correlation between psychological and neurophysiological characteristics].

A relationship between neurophysiological and psychological characteristics of attention was studied in 18 patients with schizophrenia and their 34 mentally healthy relatives: parents and siblings (20 subjects) and children (14 subjects). In patients, a decrease of P300 auditory evoked potentials significantly correlated with disturbances of attention stability and volume as well as characteristics of involuntary attention. At the same time, in the groups of relatives the anomalies of attention stability and attention in conditions of prolonged concentration were positively related to P300 latency.

[Bioelectrical activity of the brain in parents of schizophrenics].

The peculiarities of brain electric activity in mentally normal parents of schizophrenics (52 subjects) as compared to the control group of mentally normal subjects without family history of manifest psychosis (22 subjects). In both groups, EEG spectral densities and auditory evoked potentials (AEP) characteristics were compared. The parents of schizophrenics appeared to differ from controls by decrease of N1 amplitude and prolongation of N2, P3 which was similar to that observed in patients with schizophrenia.

[Genetic association between the apolipoprotein E (ApoE) gene alleles and various forms of Alzheimer's disease].

Allele epsilon 4 of the apolipoprotein E (APOE) gene is associated with higher risk of Alzheimer's disease (AD) in many, though not all, ethnic groups. The APOE allele and genotype frequency distributions were studied in 207 AD patients without cerebrovascular disorders, 62 AD patients with cerebrovascular disorders (combined AD), and 206 control individuals (ethnic Russians from the Russian population). The frequency of allele epsilon 4 in patients with early-onset and late-onset AD was three times higher than in control individuals (p < 0.

Possible neurophysiological markers of genetic predisposition to Alzheimer's disease.

Visual-evoked potentials (VEP) to a flash were studied in the first-order relatives of patients with Alzheimer's disease (AD) (mean age 38.2 +/- 2.6 years) in comparison with the patients (mean age 61.

[The search for a mutation in the gene coding the beta-amyloid protein precursor gene in patients with Alzheimer-type dementias].

Missence mutation in codon 717 of the amyloid precursor protein (APP) gene that codes for the precursor to the beta-protein found in the amyloid deposits of Alzheimer disease was recently shown to be segregated with this disease in some kindreds. The following study aimed to determine the frequency of the codon 717 mutation in familial and "sporadic" cases of dementia of the Alzheimer type has been performed in Russian patients. 62 patients with senile dementia and the Alzheimer disease with early and late onset and 43 normal controls were tested for this mutation.