[Medical rehabilitation features of patients suffered from new coronavirus infection].

Unlabelled: Despite the development and implementation of preventive measures, new coronavirus infection (COVID-19) cases are still being registered among the population.

Objective: To describe the methods of recovery treatment, used at different rehabilitation stages of patients suffered from COVID-19.

Material And Methods: An analytical review of rehabilitation methods of patients after COVID-19 was conducted.

[Obligate anaerobic microbes in obstetric and gynecologic diseases].

The paper reviews recent-years' papers and the data of their own investigations on a role of obligate anaerobic microbes in obstetric and gynecological abnormality. The fact that secondary pelvic inflammatory processes caused chiefly by non spore-forming anaerobes is ascertained. There is evidence that obligate anaerobic bacteria are involved in the abnormality directly unassociated with the development of an inflammatory process: preterm labor, premature discharge of amniotic fluid, intranatal fetal hypoxia, respiratory distress syndrome and hyaline membrane disease of the premature newborn.

[The transplacental passage and distribution of ceftazidime in the fetal and maternal organs in a 2nd-trimester abortion].

Transplacental passage of ceftazidime was studied in 17 women with second-trimester pregnancy which had to be discontinued for medical causes. A single intramuscular injection of the antibiotic resulted in creation of therapeutically active concentrations in fetal blood and organs, amniotic fluid, and placenta. Transplacental passage of ceftazidime from the mother to the fetus was 19.

[The transplacental transit and action of ceftazidime on the fetus in an experiment on animals at different times of the pregnancy].

The experiments were conducted on pregnant albino rats to study the transplacental transit of ceftazidime (Fortum) to the fetus on days 14 and 21 of pregnancy after a single intramuscular injection of 100 mg/kg. The antibiotic transition was 5.23, and 51.

[An animal experiment on transplacental transport of ceftazidime at various terms of pregnancy].

The experiments on rats revealed good transplacental transfer of ceftazidime to the fetus. The level of the transfer increased with increasing of the pregnancy term. The antibiotic concentration in the fetal tissues exceeded the MIC for opportunistic organisms.

[The formation of the normal intestinal microbiocenosis in newborn infants and under antibiotic therapy].

The dynamic study of the microecological state of the intestine in 41 newborns up to the age of 3 months has been made by biochemical and bacteriological investigation methods. The results of the biochemical rapid analysis have been found to be in complete agreement with those of the bacteriological analysis and, besides, to provide essential additional data. The biochemical rapid analysis permits the evaluation of the state resistance to the colonization of the intestine in children, starting from the age of 6 days.

[The role of nonsporulating anaerobic bacteria in the etiology of postabortion and postpartal endometritis].

As the result of the study carried out by the authors, a conclusion has been made on the leading role of polymicrobial aerobic-anaerobic complexes, capable of producing a synergic effect, in the etiology of endometritis, anaerobic microorganisms prevailing in their importance. In the etiology of endometritis the most important organisms are bacteroids and peptostreptococci among anaerobes, enterobacteria and group D streptococci among aerobes. Anaerobic bacteria causing endometritis are most sensitive to dalacin and lincomycin, least sensitive to benzylpenicillin, resistant to aminoglycosides.

[Etiological structure and antibiotic sensitivity of the causative agents of puerperal endometritis].

The study revealed the dominating role of aerobic-anaerobic microbial associations and in particular the specific role of anaerobic gram positive cocci in development of puerperal endometritis. The data suggested that a definite level of the uterus cavity contamination with microbes, not lower than 10(4)-10(5) CFU/ml or a large number of bacterial associates, not less than 3 was necessary for endometritis development. It was confirmed that pathogenicity of anaerobes increased in the presence of aerobic bacteria.

[Pharmacokinetics of cefuroxime in pregnant women with acute pyelonephritis].

The pharmacokinetics of cefuroxime was studied in 40 pregnant women with acute pyelonephritis. The women were in the 2nd and 3rd terms of pregnancy. The antibiotic was injected in a dose of 500 mg.

[Antibacterial therapy of pyelonephritis in pregnant women].

To determine the optimal schemes of rational antibacterial therapy of pyelonephritis gravidarum with ampicillin and cephuroxim, assays of the patient urine and studies on the pharmacokinetics of the drugs were performed. The bacteriurea levels were estimated in 264 women with Gould's method in modification of Ryabinsky and Rodoman. The causative agents of the disease were isolated from the urine of 92 pregnant women.

[Distribution of antibiotic-resistant microorganisms among newborn infants in an intensive care unit].

Bacteriological assay of the nasal, fauces and feces microflora of 40 newborns of the Department of Intensive Therapy revealed their primary colonization with various opportunistic microorganisms from the environment. Sensitivity of the isolates to 15 antibiotics was tested. It was shown that multiple resistance strains predominated.

[Comparative clinical efficacy of cephotaxim and cefuroxime against the pathogens of inflammation in obstetrics and gynecology].

The use of cephotaxim in the treatment of obstetric and gynecological patients with various infectious complications, as well as in the treatment of newborn infants in the Department of Intensive Therapy showed it to be highly effective in 100 per cent of the cases. The adverse reactions of cephotaxim were observed in 1 out of 43 patients. It should be noted that cephotaxim did not inhibit the host anaerobic indigenous flora.

[Transplacental passage of gentamicin and its effect on the fetus].

The time course of gentamicin transplacental penetration was studied in women during labor. It was found that the transplacental penetration of the antibiotic was high and its levels in the fetus blood were only slightly lower than those in the mother blood. The concentration of the antibiotic in the placenta and amniotic fluid was also rather high.

[Effectiveness of using cefuroxime in the obstetrics and gynecology clinic].

The clinical trials of cefuroxim in the treatment of patients with various postnatal diseases and postoperative complications caused by Staph. aureus, E. coli, Klebsiella or Proteus showed its high efficacy.