THE ASSESSMENT OF COMPENSATION OF CARBOHYDRATE METABOLISM IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH METABOLIC SYNDROME BEYOND THE LIMITS OF GLYCATED HEMOGLOBIN.

Objective: The aim: To investigate glycemic variability in type 2 diabetes patients with metabolic syndrome (MS) and to assess its effect on diabetes compensation.

Patients And Methods: Materials and methods: We used traditional indicators of glycemia variability according to the recommendations of the American Diabetes Association Professional Practice Committee. We proved that patients with type 2 diabetes mellitus with MS reliably have worse CGM indicators: Time in range TIR: (3.

[The changes of processes of free radical oxidation of lipids and proteins, antioxidant defence in rats with hypofunction of the thyroid gland in conditions of iodine and copper deficiency].

Thyroid status, copper balance, correlation of processes of peroxide oxidation of lipids (POL), proteins (POP), antioxidant defence (AOD) were examined in experiments on rats with hypofunction of thyroid gland under iodine monodeficit (HTGI) and combined iodine and copper deficit (HTGI+Cu). It was determined that a combined deficit of microelements is accompanied by a distribution of copper content between different tissues (increase in red blood cell mass and cerebrum, decrease in myocardium), essential changes of indexes of hypotalamo-hypophysis-thyroid axis, oxygen-dependent metabolism, antiradical defense, exacerbating the effects of negative influence of each of them on organism. It was established that HTGI+Cu causes a suppression of oxygen-dependent processes.

[Physiological aspects of analysis of the indexes of the variability of cardiac rhythm in adolescents with latent hypothyrosis].

We studied the parameters of variability of cardiac rhythm in adolescents with the latent hypothyrosis and in healthy individuals and the interrelationship of these parameters with the indexes of the thyroid system (hormonal status, dimensions of thyroid, median ofioduria). It has been revealed that iodine deprivation leads to vegetative dystonia with the decreased activity of the sympathetic nervous system. This is accompanied by the narrowing of the range of adaptive capabilities of the organism, exhaustion of the regulatory influences in comparison with healthy children.

[Correlation of thyroid status with indices of lipid metabolism and the level of psycho-physiologic development of children with latent hypothyrosis].

Clinic and physiologic examination of 35 children with latent hypothyrosis has been carried out. It has been established that in children with early stages of thyroid hypofunction a mental development is altered (intellect is decreasing) and psycho-motor reactions suffer (resistance, intensity of attention, speed of sensorimotor reactions are altered). Following progression of pathology, the indexes of lipid metabolism change (content of cholesterol is increasing, level of beta-lipoproteins is decreasing in blood serum).

[The changes of free radical lipid peroxidation, antioxidant system activity, nitrogen oxide level in iodo-deficient hypothyrosis].

The state of lipid peroxidation system, antioxidant defense enzyme activity, nitric oxide level during iodine defficiency hypothyrosis have been studied in the experiments on the laboratory rats. It has been established that in hypothyrosis the intensity of free-radical reactions rise greatly, nitric oxide level in blood serum decreases, antioxidant defense processes are depressed.

[Biochemical blood serum indexes in rats with hypothyroidism corrected by iodide-100 preparation].

In experiments performed on rats with hypothyrosis, the blood serum indexes (the level of triodthyronine, thyroxin, thyrothropic hormone of adenohypophysis, the level of cholesterol, triglycerides, nitric oxide) and the level of iodine excretion with urine before and after correction of iodine deficiency by "Iodide-100" drug has been studied. It has been revealed that hypothyrosis has negative influence on lipid metabolism indexes and is accompanied by decrease in nitric oxide level in blood serum. This could lead to destabilization of structure and functions of cells of different tissues of the organism.

[Characteristics of hypothyroidism correction and lipid metabolism disorder in iodine deficiency].

The serum biochemical indexes (level of triiodthyronine, thyroxin, thyrothropic hormone of adenohypophysis, level of cholesterol, triglycerides) and the level of iodine excretion with urine in rats with hypothyrosis corrected by "Iodid-100" and along with excessive intake of chlorine and fluorine ions into the organism had been studied. It has been revealed that hypothyrosis has negative influence on lipid metabolism indexes. "Iodid- 100" usage stabilized hormonal and lipid status.

[Lipid peroxidation and the antioxidant system activity of the blood serum and tissues of the stomach and brain in interoceptive stimulation of the gastrointestinal tract].

Changes of the level of lipids peroxide oxygenation and activity of antioxigenative system in blood serum and in the tissues of stomach, brain under the condition of interoceptive stimulation of the gastro-intestinal tract. Violation of correlation among the processes of free radical lipid oxidation and antioxidant defence of the organism towards activation of lipoperoxidation in the above mentioned conditions has been determined. The degree of this violation depends on the nature of the stimulus action.