Genetic Features of Tongue Cancer Recurrence in Young Adults.

To identify genetic alterations associated with tongue cancer recurrence in young adults, whole exome sequencing of the primary tumor, recurrence, and whole blood samples from young patients with tongue cancer was performed. A frameshift mutation in the TP53 gene was detected in the primary tumor and recurrence tumor tissue. A mutation in the EPHB6 gene was detected in the recurrence and was absent in the primary tumor.

Complex Analysis of Single-Cell RNA Sequencing Data.

Single-cell RNA sequencing (scRNA-seq) is a revolutionary tool for studying the physiology of normal and pathologically altered tissues. This approach provides information about molecular features (gene expression, mutations, chromatin accessibility, etc.) of cells, opens up the possibility to analyze the trajectories/phylogeny of cell differentiation and cell-cell interactions, and helps in discovery of new cell types and previously unexplored processes.

Perspectives of climate change: A comparison of scientific understanding and local interpretations by different Western Siberian communities.

We present a study of social effects of climate change as experienced by local communities, based on field research and analysis in Western Siberia, from southern taiga to tundra. The results of field anthropological research reveal different attitudes of local residents to climate change. We compare the key trends of climate change with the perspectives of local residents, based on memories, subjective experiences, and local environmental knowledge.