Prototype of Implant for Nitric Oxide Release Controlled by Infrared Radiation in Therapeutic Window.

Local therapeutic action and targeted drug release are promising approaches compared to traditional systemic drug administration. This is especially relevant for nitric oxide (NO), as its effects change dramatically depending on concentration and cellular context. Materials capable of releasing NO in deep tissues in a controlled manner might open new therapeutic opportunities.

Adrenochrome formation during photochemical decomposition of "caged" epinephrine derivatives.

Control of biological activity with light is a fascinating idea. "Caged" compounds, molecules modified with photolabile protecting group, are one of the instruments for this purpose. Adrenergic receptors are essential regulators of neuronal, endocrine, cardiovascular, vegetative, and metabolic functions.

Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY.

Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies. Here, we present a novel biocompatible material based on polydimethylsiloxane (PDMS) doped with BODIPY derivatives containing an N-nitroso moiety that is capable of the photoinduced generation of NO.

Ab Initio Study of the Electronic Properties of a Silicene Anode Subjected to Transmutation Doping.

In the present work, the electronic properties of doped silicene located on graphite and nickel substrates were investigated by first-principles calculations method. The results of this modeling indicate that the use of silicene as an anode material instead of bulk silicon significantly improves the characteristics of the electrode, increasing its resistance to cycling and significantly reducing the volume expansion during lithiation. Doping of silicene with phosphorus, in most cases, increases the electrical conductivity of the anode active material, creating conditions for increasing the rate of battery charging.

Oxidative [3+2]Cycloaddition of Alkynylphosphonates with Heterocyclic -Imines: Synthesis of Pyrazolo[1,5-]Pyridine-3-phosphonates.

A series of pyrazolo[1,5-]pyridine-3-ylphosphonates were prepared with moderate to good yields by the oxidative [3+2]cycloaddition of 2-subtituted ethynylphosphonates with in situ generated pyridinium-N-imines and their annulated analogs. 2-Aliphatic and 2-Ph acetylenes demonstrate low activity, and the corresponding pyrazolopyridines were achieved with a moderate yield in the presence of 10 mol% Fe(NO)·9HO. At the same time, tetraethyl ethynylbisphosphonate, diethyl 2-TMS- and 2-OPh-ethynylphosphonates possess much greater reactivity and the corresponding pyrazolo[1,5-]pyridines, and their annulated derivatives were obtained with good to excellent yields without any catalyst.

Electronic Properties and Structure of Silicene on Cu and Ni Substrates.

Silicene, together with copper or nickel, is the main component of electrodes for solar cells, lithium-ion batteries (LIB) and new-generation supercapacitors. The aim of this work was to study the electronic properties and geometric structure of "silicene-Ni" and "silicene-Cu" systems intended for use as LIB electrodes. The densities of electronic states, band structures, adhesion energies and interatomic distances in the silicene-(Cu, Ni) systems were determined by ab initio calculations.

Non-covalent anion structures in dissociative electron attachment to some brominated biphenyls.

The present work combines experiment and theory to reveal the behavior of bromo-substituted-biphenyls after an electron attachment. We experimentally determine anion lifetimes using an electron attachment-magnetic sector mass spectrometer instrument. Branching ratios of dissociative electron attachment fragments on longer timescales are determined using the electron attachment-quadrupole mass spectrometer instrument.

An Ab Initio Study of Lithization of Two-Dimensional Silicon-Carbon Anode Material for Lithium-Ion Batteries.

This work is devoted to a first-principles study of changes in the structural, energetic, and electronic properties of silicene anodes during their lithium filling. Anodes were presented by silicene on carbon substrate and free-standing silicene. The ratio of the amount of lithium to silicon varied in the range from 0.

Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe.

Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a novel small-molecule fluorescent probe based on 9(10)acridone moiety for nitric oxide sensing.

Stretchable Transparent Light-Emitting Diodes Based on InGaN/GaN Quantum Well Microwires and Carbon Nanotube Films.

We propose and demonstrate both flexible and stretchable blue light-emitting diodes based on core/shell InGaN/GaN quantum well microwires embedded in polydimethylsiloxane membranes with strain-insensitive transparent electrodes involving single-walled carbon nanotubes. InGaN/GaN core-shell microwires were grown by metal-organic vapor phase epitaxy, encapsulated into a polydimethylsiloxane film, and then released from the growth substrate. The fabricated free-standing membrane of light-emitting diodes with contacts of single-walled carbon nanotube films can stand up to 20% stretching while maintaining efficient operation.

Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection.

The presence of IgG and IgM antibodies in the venous blood of 76 patients with confirmed COVID-19 infection was determined by ELISA using Russian test systems. Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG antibodies to the whole virion antigen and recombinant antigens showed high values on weeks 4-5 of the disease.

Determination of Bactericidal Activity Spectrum of Recombinant Endolysins of ECD7, Am24, Ap22, Si3, and St11 Bacteriophages.

The bactericidal activity of recombinant endolysins LysECD7, LysAm24, LysAp22, LysSi3 and LysSt11 was assayed in multidrug resistant strains (n=120) of Salmonella enterica, E. coli, Acinetobacter baumannii, Enterobacter spp., Pseudomonas aeruginosa, Klebsiella pneumoniae, and Campylobacter jejuni.

[Total laparoscopic retrieval of a cava filter: case series].

Despite the fact that prevention and treatment of venous thromboembolic complications are based on anticoagulant therapy in cases where there are contraindications, complications, as well as in case of inefficiency of the carried out anticoagulant therapy, installation of a cava filter is indicated. The necessity of subsequent retrieval of this device from the inferior vena cava is associated with a potential risk of the development of complications. Analysed herein is a case series concerning management of 4 patients undergoing treatment from February 2015 to March 2017.

Photolysis of dimethoxynitrobenzyl-"caged" acids yields fluorescent products.

Carboxylic acids conjugated with 4,5-dimethoxy-2-nitrobenzyl photoremovable protecting group are well known and widely used for biological studies. In this paper, we study the photolysis of likewise "caged" acetic, caprylic and arachidonic acids. Unexpectedly, we observed huge growth of fluorescence emission at ~430 nm during photolysis.

[Head surgery in the pictorial art of the past].

Purpose: The study purpose is to explore the early history of head surgery in terms of artistic figures, based on authentic artistic artifacts of the past.

Material And Methods: We performed a detailed analysis of many paintings, engravings, and illustrations for medical publications of the Middle Ages and Renaissance, which were definitely related to the early development of head surgery.

Results: The article summarizes a variety of illustrations that present the history of head surgery through images created by painters of the past, both recognized geniuses and those whose names have not been known to a non-specialist audience.

4-Bromobiphenyl: Long-lived molecular anion formation and competition between electron detachment and dissociation.

Electron attachment to the 4-bromobiphenyl molecule and the decay channels of its molecular anion were investigated by means of Dissociative Electron Attachment (DEA) spectroscopy with two different spectrometers. The first apparatus is equipped with a static magnet mass analyzer (Ufa group) and the second one with a quadrupole mass filter (Prague group). The dominant DEA channel at low electron energy leads to formation of Br negative fragments.

Fragmentation of chlorpyrifos by thermal electron attachment: a likely relation to its metabolism and toxicity.

The energies of formation and dissociative decays of temporary negative ions of the organophosphorus insecticide chlorpyrifos (CPF) are studied using electron transmission spectroscopy (ETS), dissociative electron attachment spectroscopy (DEAS) and quantum-chemical calculations. Three features are displayed by ETS at 2.4, 3.

New approach toward the synthesis of deuterated pyrazolo[1,5-]pyridines and 1,2,4-triazolo[1,5-]pyridines.

An efficient and operationally simple synthesis of 7-deuteropyrazolo[1,5-]pyridine and 7-deutero-1,2,4-triazolo[1,5-]pyridine derivatives using α-H/D exchange of 1-aminopyridinium cations in basic DO followed by a 1,3-cycloaddition of acetylenes and nitriles is presented. A high regioselectivity and a high degree of deuterium incorporation were achieved. The procedure was applied for several 4-R-1-aminopyridinium cations (R = H, Me, OMe).

Hemispherectomy in the treatment of pediatric symptomatic epilepsy of children.

Introduction And Purpose: Hemispherectomy is a recognized option in the treatment of symptomatic forms of intractable focal epilepsy in patients with developmental brain malformations and some acquired lesions of one the hemispheres. The prognosis for an outcome of the technique is important in terms of the indications for surgical treatment.

Material And Methods: We described the hemispherectomy technique and its variants and analyzed our own experience of surgery in 40 children.

Comparison of electrocorticographic patterns with focal cortical dysplasia types in children with epilepsy.

Objective: the objective of the study was to determine significant differences in electrocorticographic patterns for various types of focal cortical dysplasias.

Material And Methods: 42 patients diagnosed with drug-resistant focal epilepsy were operated on at the Burdenko Neurosurgical Institute in the period from 2006 to 2013. Patients who were histologically diagnosed with focal cortical dysplasia (FCD) and underwent video-electroencephalography and electrocorticography were analyzed.

Electron attachment to the phthalide molecule.

Phthalide, the simplest chain of conductive polymer thin film, was investigated by means of Electron Transmission Spectroscopy, Negative Ion Mass Spectrometry, and density functional theory quantum chemistry. It has been found that formation of gas-phase long-lived molecular anions of phthalide around 0.7 eV takes place through cleavage of a C-O bond of the pentacyclic ring of the parent molecular anion to give a vibrationally excited (electronically more stable) open-ring molecular anion.

[Cryoablation in urology].

Modern science opens up new potentials for the effective treatment of complex diseases using minimally invasive techniques. One of the obvious achievements of recent years is cryoablation - technology of local freezing of tissues, allowing to create a precision zone of tumor cell death in renal cancer and prostate cancer. The literature review presents historical information, highlighting the main stages in the development of cryosurgery since the XIX century.

[THE QUALITY OF EXAMINATION OF PATIENTS WITH ARTERIAL HYPERTENSION BASED AT OUTPATIENT FACILITIES].

Aim: To analyze the quality of application of diagnostic methods in patients with arterial hypertension (AH) based at outpatient facilities in comparison with equipments of national clinical recommendations.

Materials And Methods: The study was conducted in the framework of the outpatient registry of cardiovascular diseases (REKVAZA). It included analysis of outpatient medical cards of 2850 patients with AH examined in two municipal polyclinics.