Morphine-induced side effects can be differentially modulated by cannabidiol in male and female rats.

Opioid use disorder is a public health problem that includes symptoms such as withdrawal syndrome and opioid-induced hyperalgesia. Currently, drugs to treat side effects of opioids also have undesirable effects, which lead to limitations. This study investigated the effect of a treatment with cannabidiol in morphine-induced hyperalgesia and withdrawal behavior in morphine-dependent rats.

Seraph 100 Microbind Affinity Blood Filter Does Not Clear Antibiotics: An Analysis of Antibiotic Concentration Data from PURIFY-OBS.

Introduction: Novel hemoperfusion systems are emerging for the treatment of sepsis. These devices can directly remove pathogens, pathogen-associated molecular patterns, cytokines, and other inflammatory markers from circulation. However, significant safety concerns such as potential antibiotic clearance need to be addressed prior to these devices being used in large clinical studies.

Microwave-assisted extraction based on emulsion breaking with natural deep eutectic solvent for vegetable oil sample preparation prior to elemental determination by ICP OES.

This study presents a novel and efficient method for the extraction of Al, Ca, Cr, Cu, K, Mg, Mn, and Zn in vegetable oil samples using a Natural Deep Eutectic Solvent (NADES) as an extractor combined with microwave radiation (MW) in an emulsion system. The NADES prepared with choline chloride:oxalic acid:water (1:1:4 molar ratio) provided a high extraction rate using 5.0 mL of the sample, 1.

Acute Diffusion-Weighted Imaging Signaling Severe Periventricular Leukomalacia in Preterm Infants: Case Report and Review of Literature.

Periventricular leukomalacia occurs in up to 25% of very preterm infants resulting in adverse neurodevelopmental outcomes. In its acute phase, periventricular leukomalacia is clinically silent. Although ultrasonography is widely available, its sensitivity in the early detection of periventricular leukomalacia is low.

Amplitude-Integrated Electroencephalography Evolution and Magnetic Resonance Imaging Injury in Mild and Moderate to Severe Neonatal Encephalopathy.

Objective: This study aimed to describe the evolution of amplitude-integrated electroencephalography (aEEG) in neonatal encephalopathy (NE) during therapeutic hypothermia (TH) and evaluate the association between aEEG parameters and magnetic resonance imaging (MRI) injury.

Study Design: aEEG data of infants who underwent TH were reviewed for background, sleep wake cycling (SWC), and seizures. Conventional electroencephalography (cEEG) background was assessed from the reports.

Development of Folate-Group Impedimetric Biosensor Based on Polypyrrole Nanotubes Decorated with Gold Nanoparticles.

In this study, polypyrrole nanotubes (PPy-NT) and gold nanoparticles (AuNPs) were electrochemically synthesized to form a hybrid material and used as an electroactive layer for the attachment of proteins for the construction of a high-performance biosensor. Besides the enhancement of intrinsic conductivity of the PPy-NT, the AuNPs act as an anchor group for the formation of self-assembly monolayers (SAMs) from the gold-sulfur covalent interaction between gold and Mercaptopropionic acid (MPA). This material was used to evaluate the viability and performance of the platform developed for biosensing, and three different biological approaches were tested: first, the Avidin-HRP/Biotin couple and characterizations were made by using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), wherein we detected Biotin in a linear range of 100-900 fmol L.

Association of early cerebral oxygen saturation and brain injury in extremely preterm infants.

Objective: To assess the association between cerebral saturation (crSO) using Near-Infrared Spectroscopy (NIRS) and brain injury in extremely preterm infants.

Study Design: This retrospective study includes 62 infants (<28 weeks gestation) who underwent continuous NIRS monitoring in the first 5 days after birth. Median crSO were compared in 12 h increments between infants with and without germinal matrix/intraventricular hemorrhage (GM/IVH).

Development of polypyrrole (nano)structures decorated with gold nanoparticles toward immunosensing for COVID-19 serological diagnosis.

The rapid and reliable detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroconversion in humans is crucial for suitable infection control. In this sense, many studies have focused on increasing the sensibility, lowering the detection limits and minimizing false negative/positive results. Thus, biosensors based on nanoarchitectures of conducting polymers are promising alternatives to more traditional materials since they can hold improved surface area, higher electrical conductivity and electrochemical activity.

Association of Major Depressive Symptoms With Endorsement of COVID-19 Vaccine Misinformation Among US Adults.

Importance: Misinformation about COVID-19 vaccination may contribute substantially to vaccine hesitancy and resistance.

Objective: To determine if depressive symptoms are associated with greater likelihood of believing vaccine-related misinformation.

Design, Setting, And Participants: This survey study analyzed responses from 2 waves of a 50-state nonprobability internet survey conducted between May and July 2021, in which depressive symptoms were measured using the Patient Health Questionnaire 9-item (PHQ-9).

Cumulative effects of human footprint, natural features and predation risk best predict seasonal resource selection by white-tailed deer.

Land modified for human use alters matrix shape and composition and is a leading contributor to global biodiversity loss. It can also play a key role in facilitating range expansion and ecosystem invasion by anthrophilic species, as it can alter food abundance and distribution while also influencing predation risk; the relative roles of these processes are key to habitat selection theory. We researched these relative influences by examining human footprint, natural habitat, and predator occurrence on seasonal habitat selection by range-expanding boreal white-tailed deer (Odocoileus virginianus) in the oil sands of western Canada.

Association Between Social Media Use and Self-reported Symptoms of Depression in US Adults.

Importance: Some studies suggest that social media use is associated with risk for depression, particularly among children and young adults.

Objective: To characterize the association between self-reported use of individual social media platforms and worsening of depressive symptoms among adults.

Design, Setting, And Participants: This survey study included data from 13 waves of a nonprobability internet survey conducted approximately monthly between May 2020 and May 2021 among individuals aged 18 years and older in the US.

Blood gas measures as predictors for neonatal encephalopathy severity.

Objective: To correlate arterial umbilical cord gas (aUCG) and infant blood gas with severity of neurological injury.

Study Design: Retrospective single-site study of infants evaluated for therapeutic hypothermia. Clinical neurological examination and a validated MRI scoring system were used to assess injury severity.