[Characteristics of antibiotic therapy in neonates with polyorgan insufficiency].

Polyorgan insufficiency (POI) is the main cause of death in ISU patients. The highest rates of morbidity and mortality due to POI are recorded among newborns. Antibbacterial therapy of probable infections processes is widely used in neonatology, however long-term antibacterial therapy is not favouable for newborn infants.

[Clinical significance of ontogenetic abnormalities of hemoglobin synthesis].

Hemoglobin consists of four globin chains linked by 4 hem molecules. Differences between hemoglobin species are due to dissimilarity of amino acid sequence in globin chains accounting for different solubility, affinity to oxygen, and interaction with nitrogen. The hem component is the same in all hemoglobins.

[Efficiency of emoxipine in treatment of multiple organ failure in newborns].

Prospective, placebo-controlled, simple "blind" randomized study of the effect of emoxipine (2-ethyl-6-methyl-3-oxypyridine hydrochloride) on the dynamics of central hemodynamics, content of lipid peroxidation products in tracheo-bronchial lavage, and severity of clinical sickness was performed in newborn children with multiple organ failures (MOF). The obtained results showed that a 10-day course of the intravenous administration of emoxipine in a single dose of 10 mg/kg improved the systolic function of myocardium of left ventricle, limited lipid peroxidation in broncho-pulmonary system, and increased oxygen delivery to tissues. These effects of emoxipine were accompanied by a clinically significant improvement of neurological status, reduction of the need for artificial ventilation of lungs, and decrease of mortality in newborns with MOF diagnosis.

[Microbiocenosis of stomach in children with chronic gastritis].

Qualitative and quantitative composition of gastric microflora has been studied in 30 children with chronic gastritis. Bacteriological study of gastric biopsies and parietal mucus in 10 children with chronic gastritis not associated with Helicobacter pylori more frequently revealed conditionally pathogenic bacteria--Escherichia coli, Staphylococcus aureus, Streptococcus viridans, S. pyogenes (group A), Peptostreptococcus anaerobius, P.

[Functional condition of autonomic nervous system in children with chronic gastroduodenal pathology].

A study was made of autonomic nervous system function in 125 children with chronic gastroduodenal pathology. Of these, 37 children presented with peptic ulcer, 36 with erosive processes occurring in the gastroduodenal area, and 52 with superficial gastroduodenitis. The status of the autonomic nervous system was evaluated according to the initial vegetative tone, vegetative reactivity, and vegetative supply of the activity in carrying out cardiointervalography and the clinoorthostatic test.