Prophylaxis of decidual CD68/CD163 macrophage disbalance in extracorporeal fertilized women.

Unlabelled: The demographic crisis that prevailed in Ukraine in recent years, the state of war as a result of the aggression of the Russian Federation, reproductive losses among women of childbearing age are one of the most urgent problems in modern obstetrics and gynecology. One of the most effective methods of correcting impaired reproductive function is in vitro fertilization.

The Purpose Of This Work: is to develop a pharmacological complex for the prevention of imbalance of CD68/CD163 decidual macrophages in vitro fertilized women.

THE ROLE OF SECRETING FUNCTION OF DECIDUA IN THE DEVELOPMENT OF COMPLICATIONS OF GESTATION PROCESS IN PREGNANT WOMEN WITH A PAST HISTORY OF CHRONIC ENDOMETRITIS.

Objective: The aim: To determine the serum FAMG in the I and II trimester of pregnancy in women with a past history of chronic endometritis, and to clarify its impact on the development of pathology of pregnancy.

Patients And Methods: Materials and methods: The level of FAMG was determined at 6-8 and 16-18 weeks of gestation in 135 pregnant women with a past history of chronic endometritis, who received treatment of chronic endometritis at the stage of pregravid preparation and 168 women who became pregnant without its prior treatment. The dependence of the development of pre-eclampsia on the level of FAMG at the early stages of pregnancy has been evaluated.

Changes of psycho-emotional state in the infertile pregnant females due to the anamnesis and IVF.

Objective: Introduction: During pregnancy in the body of a healthy woman there are physiological and psychological changes that contribute to the bearing a child and prepare the female for future labour and motherhood. In women who experience failure at the stage of fertilization or during pregnancy, as a result of prolonged negative emotional states, psycho-emotional stress develops. The aim of the research was to study the psycho-emotional state of women with infertility in history, whose pregnancy resulted from extracorporal fertilization (IVF), and to develop methods for reducing their anxiety.

Possibility for non-invasive diagnosis of chronic endometritis in women at risk during pregravid preparation.

Objective: Introduction: Detection and treatment of chronic endometritis (CE) is clinically significant, though involves intrauterine intervention to collect endometrium. The aim: To estimate the possibility to use fertility α2-microglobulin (FAMG) as the marker of the high risk for CE.

Patients And Methods: Materials and methods: 70 women with CE who were planning pregnancy were tested for FAMG in menstrual blood.

Role of uterine blood flow disturbances in the development of late gestosis.

Objective: Introduction: Chronic endometritis (CE) associated lesions lessen the implantation potential of endometrium and aggravate the course of invasive processes in the uterine vessels The aim: Study of changes in doplerometric parameters of blood flow in spiral and uterine arteries in 17-18 weeks of pregnancy in women with СE in anamnesis.

Patients And Methods: Materials and methods: Сalculation of systolic/diastolic ratio (SDR), pulse index (PI) and resistive index (RI) has been carried out in 70 pregnant had CE in past history and 10 healthy pregnant women who experienced neither chronic endometritis before pregnancy nor preeclampsia.

Results: Results: SDR in SA patients with CE in history and follow-up development of preeclampsia is by 19& higher the control values (р<0,05); PI was 85& higher than the similar one in the control group and RI was 86& higher (р<0,01).

Risk markers of reproductive loss in women with hyperandrogenism.

Objective: Introduction: The frequency of the pathological course of pregnancy with hyperandrogenism ranges from 21 to 48%. With the predominance of androgens against the background of lowering the normal products of steroidogenesis, a pro-inflammatory immune imbalance is formed, which causes a premature termination of the development of pregnancy. Many studies indicate that hyperandrogenism is a factor in the development of obstetric pathology, including placental dysfunction.