Publications by authors named "Vollmer D"

Objectives: Natural killer (NK) cells are important immune system effector cells providing innate defenses against intracellular infections, including viral infections, immune surveillance, and cancer immunoediting. The primary purpose of this study was to investigate whether modified ultra-filtrated colostrum (UC) and hydrolyzed whey (W) products or their combinations with other natural products with reported immunomodulatory properties will stimulate NK cell cytotoxic activity by activation of granzyme B and IFN-γ production.

Methods: The ability of study products to stimulate the cytotoxic activity of human-purified CD56 NK cells and the production of granzyme B and IFN-γ by activated NK cells was evaluated in the cytotoxic assay.

View Article and Find Full Text PDF

Many current and upcoming laser facilities used to study high-energy-density (HED) physics and inertial fusion energy (IFE) support operating at high rep-rates (HRRs) of ∼0.1-10 Hz, yet many diagnostics, target-fielding strategies, and data storage methods cannot support this pace of operation. Therefore, established experimental paradigms must change for the community to progress toward rep-rated operation.

View Article and Find Full Text PDF

Bicarbonate and CO are essential substrates for carboxylation reactions in bacterial central metabolism. In , the bicarbonate transporter, MpsABC (membrane potential-generating system) is the only carbon concentrating system. An deletion mutant can hardly grow in ambient air.

View Article and Find Full Text PDF

Background And Objectives: Patients with diskitis/osteomyelitis who do not respond to medical treatment or develop spinal instability/deformity may warrant surgical intervention. Irregular bony destruction due to the infection can pose a challenge for spinal reconstruction. The authors report a lateral approach using patient-specific interbody cages combined with posterior or lateral instrumentation to achieve spinal reconstruction for spinal instability/deformity from spondylodiskitis.

View Article and Find Full Text PDF

Silicone is frequently used as a model system to investigate and tune wetting on soft materials. Silicone is biocompatible and shows excellent thermal, chemical, and UV stability. Moreover, the mechanical properties of the surface can be easily varied by several orders of magnitude in a controlled manner.

View Article and Find Full Text PDF

In the model organism Bacillus subtilis, a signaling protease produced in the forespore, SpoIVB, is essential for the activation of the sigma factor σ, which is produced in the mother cell as an inactive pro-protein, pro-σ. SpoIVB has a second function essential to sporulation, most likely during cortex synthesis. The cortex is composed of peptidoglycan (PG) and is essential for the spore's heat resistance and dormancy.

View Article and Find Full Text PDF

Understanding the dynamics of drops on polymer-coated surfaces is crucial for optimizing applications such as self-cleaning materials or microfluidic devices. While the static and dynamic properties of deposited drops have been well characterized, a microscopic understanding of the underlying dynamics is missing. In particular, it is unclear how drop dynamics depends on the amount of uncross-linked chains in the brush, because experimental techniques fail to quantify those.

View Article and Find Full Text PDF

Slide electrification is the spontaneous separation of electric charges at the rear of water drops sliding over solid surfaces. This study delves into how surfaces treated with a low-pressure plasma impact water slide electrification. Ar, O, and N plasma treatment reduced the drop charge and contact angles on glass, quartz, and SU-8 coated with 1H,1H,2H,2H-perfluoroctyltrichlorosilane (PFOTS), and polystyrene.

View Article and Find Full Text PDF

Strongly attractive forces act between superhydrophobic surfaces across water due to the formation of a bridging gas capillary. Upon separation, the attraction can range up to tens of micrometers as the gas capillary grows, while gas molecules accumulate in the capillary. We argue that most of these molecules come from the pre-existing gaseous layer found at and within the superhydrophobic coating.

View Article and Find Full Text PDF

Background: Many natural products have immunomodulatory properties. However, the mechanism of immunomodulatory activities are poorly understood.

Objectives: This study evaluated the influence of bovine colostrum products, a whey product, or their combinations with other natural products on human peripheral blood mononuclear cells' (PBMC) ability to produce cytokines upon activation.

View Article and Find Full Text PDF

Telomerase activity coincides with lengthening of the ends of chromosomes known as telomeres. Telomere length is used as a marker for cellular aging. Telomeres shorten over time as cells divide, and certain bioactive compounds such as gold nanoparticles (AuNPs) may slow the shortening of telomeres by increasing telomerase activity.

View Article and Find Full Text PDF

The formation of a bridging gas capillary between superhydrophobic surfaces in water gives rise to strongly attractive interactions ranging up to several micrometers on separation. However, most liquids used in materials research are oil-based or contain surfactants. Superamphiphobic surfaces repel both water and low-surface-tension liquids.

View Article and Find Full Text PDF

Methods for fabricating super-liquid-repellent surfaces have typically relied on perfluoroalkyl substances. However, growing concerns about the environmental and health effects of perfluorinated compounds have caused increased interest in fluorine-free alternatives. Polydimethylsiloxane (PDMS) is most promising.

View Article and Find Full Text PDF

Drops in contact with swollen, elastomeric substrates can induce a capillary mediated phase separation in wetting ridges. Using confocal microscopy, we visualize phase separation of oligomeric silicone oil from a cross-linked silicone network during steady-state sliding of water drops. We find an inverse relationship between the oil tip height and the drop sliding speed, which is rationalized by competing transport timescales of the oil molecules: separation rate versus drop-advection speed.

View Article and Find Full Text PDF

Wetting imperfections are omnipresent on surfaces. They cause contact angle hysteresis and determine the wetting dynamics. Still, existing techniques (e.

View Article and Find Full Text PDF

Peptidoglycan (PG) is an essential component of the cell envelope in most bacteria, responsible for maintaining the shape of the cell and protecting the cell from environmental stresses. The growth of the PG layer during cell elongation and division is facilitated by the coordinated activities of PG synthases and hydrolases. PG synthases are regulated from inside the cell by components of the elongasome and divisome complexes driven by the cytoskeletal proteins MreB and FtsZ.

View Article and Find Full Text PDF

We study the equilibrium properties and the wetting behavior of a simple liquid on a polymer brush, with and without the presence of lubricant by multibody Dissipative Particle Dynamics simulations. The lubricant is modeled as a polymeric liquid consisting of short chains that are chemically identical with the brush polymers. We investigate the behavior of the brush in terms of the grafting density and the amount of lubricant present.

View Article and Find Full Text PDF

Objective: This study was undertaken to explore the effects of a bovine colostrum-containing multivitamin multimineral (MVM) supplement on healthy, adult women and men by determining blood chemistries and health parameters via serum and saliva sampling and measuring each subject's physical characteristics over a 12-week interval.

Participants: Fifty participants were screened for the study, after which twenty participants were determined eligible to enter the study. Thirteen participants (6 women and 7 men, average age 30.

View Article and Find Full Text PDF

The purpose of this clinical study was to determine whether gold nanoparticle (AuNP) supplementation at a dosage of 0.34 mg elemental gold per day can improve knee joint health, function, and quality of life for arthritis patients. A total of 51 participants (24 male and 27 female, age 62.

View Article and Find Full Text PDF

Akkermansia muciniphila is an intestinal symbiont known to improve the gut barrier function in mice and humans. Various cell envelope components have been identified to play a critical role in the immune signaling of A. muciniphila, but the chemical composition and role of peptidoglycan (PG) remained elusive.

View Article and Find Full Text PDF

Ecosystems provide a range of services, including water purification, erosion prevention, and flood risk mitigation, that are important to water resource managers. But as a sector, water resources management has been slow to incorporate ecosystem protection and restoration, for a variety of reasons, although related concepts such as nature-based solutions and green infrastructure are gaining traction. We explain some of the existing challenges to wider uptake of the ecosystem services concept in water resources management and introduce some promising avenues for research and practice, elaborated in more detail through 12 papers, spanning five continents and a variety of contexts, which make up a Special Issue on "Incorporating Ecosystem Services into Water Resources Management".

View Article and Find Full Text PDF

Introduction The use of scaffolds in tissue engineering is becoming increasingly important as solutions need to be found for the problem of preserving human tissue, such as bone or cartilage. In this work, scaffolds were printed from the biomaterial known as polycaprolactone (PCL) on a 3D Bioplotter. Both the external and internal geometry were varied to investigate their influence on mechanical stability and biocompatibility.

View Article and Find Full Text PDF