Assembly of nuclear pore complexes mediated by major vault protein.

During interphase growth of eukaryotic cells, nuclear pore complexes (NPCs) are continuously incorporated into the intact nuclear envelope (NE) by mechanisms that are largely unknown. De novo formation of NPCs involves local fusion events between the inner and outer nuclear membrane, formation of a transcisternal membranous channel of defined diameter and the coordinated assembly of hundreds of nucleoporins into the characteristic NPC structure. Here we have used a cell-free system based on Xenopus egg extract, which allows the experimental separation of nuclear-membrane assembly and NPC formation.

Lipoaspirate-derived adult mesenchymal stem cells improve functional outcome during intracerebral hemorrhage by proliferation of endogenous progenitor cells stem cells in intracerebral hemorrhages.

Stem cell therapy seems promising in reducing deficits after focal cerebral ischemia. As stroke may result from intracerebral hemorrhage (ICH) in up to 20% we investigated whether human processed lipoaspirate mesenchymal stem cells (PLA-MSC) influence the functional outcome, migration behavior and the activation of endogenous progenitor cells. Experimental ICH was induced by stereotactic administration of collagenase in rats randomly assigned to the control or treatment group.

[Ectopic pregnancy--still a challenge in gynecology. A contribution to diagnosis and therapy].

The diagnostic and therapeutic management in 80 cases with ectopic pregnancy is analysed. Only in 36 cases (45%) there was an accordance of installation diagnosis with the intraoperative status. 44 patients (55%) were suspicious to suffer from acute pelvic inflammatory disease, abortion or irregular uterine bleedings.

[Problems of agreement of clinical and autopsy diagnoses].

Results obtained from autopsy are parameters of importance to efficacy of diagnosis and therapy. To enable better overseeability of higher numbers of cases, the necessary congruence between clinical and postmortem diagnoses should be consistently settled on the basis of identical criteria used by clinicians and pathologists. Aspects relating to the problem are discussed in some detail, and suggestions are made on how to formulate final evaluations in postmortem reports.

[Postpartum curettage--is it always indicated?].

Within five years (1982-1986) there were in the Dept. Obstet. Gynec.

[Myocardial infarction without coronary artery changes].

Since 1972 6 patients (4 males and 2 females) at the age from 18 to 44 years with myocardial infarctions could be observed whose coronary system in the subsequent coronarographic examinations proved to be unconspicuous. The diagnosis of the infarction was anamnestically, laboratory-chemically, electrocardiographically and partly scintigraphically ascertained. Issuing from features of infarction and pseudoinfarction, respectively, in the ECG other differential-diagnostically important cardiac and extracardiac causes could be excluded.

Barrett-esophagus following total gastrectomy. A contribution to it's pathogenesis.

We have undertaken esophagoscopy 1/2 to 17 1/2 years after surgery in 20 patients with a total gastrectomy and an esophago-jejunal anastomosis. In 5 cases we found a complete columnar lining of the distal esophagus (Barrett-esophagus). 2 other cases showed a multilocular columnar epithelium.

[Coronary atherosclerosis, coronary thrombosis and myocardial infarction in autopsy cases. 9th communication: relationship of coronary thrombosis and myocardial infarction (author's transl)].

The autopsy reports of the Pathological Institute Erfurt of the period from 1.1.1951 until 31.

[Coronary atherosclerosis, coronary thrombosis and myocardial infarction in autopsy cases. 8th communication: Relationship of coronary atherosclerosis and myocardial infarction (author's transl)].

The autopsy reports of the Pathological Institute Erfurt of the period from 1.1.1951 until 31.

[Methods of induction of a coronary thrombosis by means of direct current in the closed dog and dwarf swine thorax].

Coronary thrombosis is a perilous disease. Animal experiments may contribute to investigate its pathogenesis and treatment. The development of an experimental model of coronary thrombosis on closed thorax is important.

[Clinico-endoscopic problems in malignant changes of the gastric stump].

The authors give a report on occasional difficulties concerning the radiological and endoscopic clarification of the malignant changes at the gastric stump after treatment of resection. Four relevant cases are stated and explained. The endoscopy (glass fibre gastroscopy) together with the biopsy is at present the most reliable method for the diagnosis of the pathological processes in the remaining part of the stomach.

[Coronary atherosclerosis, coronary thrombosis and myocardial infarction in autopsy cases. VII. Communication: Complications in myocardial infarctions (author's transl)].

2393 cases of myocardial infarctions autopsied during the period from 1.1. 1951 until 31.

[Myocardial infarctions without stenosing artery selerosis of thrombosis ofthe coronary arteries (author's transl)].

At autopsies between 1951 and 1969, 246 of 2393 cases with myocardial infarctions and heart muscle scars showed no thrombi and no artery sclerosis to be worth mentioning. The 7 comprehensive morphologically investigated observations of a second case group were discovered in a prospective study from 1970 to 1973. This study included 255 cases with myocardial infarctions or heart muscle scars.

[Paraneoplastic hypoglycemia due to malignant histiocytoma (Doege-Potter syndrome) (author's transl)].

A case report is given on a male patient who was 52 years old when he died. 9 years ago a nephrectomy was performed because of a densely-packed mesenchymal tumor of the adipose tissue of the pelvis renalis. 7 years after the surgical intervention he suffered from several hypoglycemic crises.

[Experimental model of coronary thrombosis in the closed thorax in swine].

Coronary thrombosis was induced in 14 miniature pigs by means of direct current. The induction electrode was introduced via the common carotid artery into the coronary artery. The intensity of current (1 mA) and the duration of current flow (60 min) were kept constant in all the experimental animals.

[Coronary atherosclerosis, coronary thrombosis and myocardial infarction in autopsy cases (author's transl)].

The autopsy reports of the Pathological Institute Erfurt of the period from 1. 1. 1951 until 31.

[Coronary artherosclerosis, coronary thrombosis and myocardial infarction in autopsy cases (author's transl)].

The autopsy reports of the Pathological Institute Erfurt of the period from 1.1. 1951 untile 31.

[Coronary atherosclerosis, coronary thrombosis and myocardial infarction in autopsy cases. 4th communication: coronary thrombosis (author's transl)].

28978 cases of young (after the 14th year of age) and adult patients autopsied during the period from 1.1 1951 until 31. 12.

[Coronary atherosclerosis, coronary thrombosis and myocardial in autopsy cases. Statistical studies. 3rd communication: relationship of coronary atherosclerosis of other arteries (author's transl)].

28978 autopsy reports of young (after the 14th year of age) and adult patients autopsied during the period of 1.1 1951 until 31. 12.

[Coronary atherosclerosis, coronary thrombosis and myocardial infarction in autopsy cases (author's transl)].

The autopsy reports of the Pathological Institute Erfurt of the period from 1.1 1951 until 31.12.

[Morphologic investigations on experimental coronary thromboses in pigs (author's transl)].

With the aid of a standardized method basing on a report of Salazar (1961) coronary thromboses in pigs were produced by means of electric induction without opening the chest. 12 of 13 pigs showed thromboses in coronary arteries, in 8 animals with embolization of the thrombotic material. At the sametime in 8 pigs a myocardial infarction could be registered.