Bilateral Versus Unilateral Repair of Nasal Septal Perforation: A Two-Center Retrospective Study.

Background: There are two main approaches for nasal septal perforation (NSP) surgery-bilateral and unilateral repair. There are advantages and disadvantages to each of these techniques. At the same time, there is a lack of comparative studies on the effectiveness of these approaches.

Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine.

Monoterpene indole alkaloids (MIAs) make up a highly bioactive class of metabolites produced by a range of tropical and subtropical plants. The corynanthe-type MIAs are a stereochemically complex subclass with therapeutic potential against a large number of indications including cancer, psychotic disorders, and erectile dysfunction. Here, we report yeast-based cell factories capable of de novo production of corynanthe-type MIAs rauwolscine, yohimbine, tetrahydroalstonine, and corynanthine.

[Assessment of efficacy of allergen immunotherapy in children and adults with allergic rhinitis].

The goal of the work toassessment of efficacy and safety of allergen immunotherapy in children and adults with allergic rhinitis, and to conduct a comparative assessment of the effectiveness of subcutaneous (SCIT) and sublingual variant (SLIT) immunotherapy. We have analyzed the medical documentation of patients during the application of allergen immunotherapy for 5 years in 710 patients with allergic rhinitis (AR). According to the results of the validated scale analysis, the clinical efficacy parameters of SCIT and SLIT after a year, 2, 3, and also after 4 and 5 years of therapy were comparable in both children and adults.

Electrophysiological correlations of morphological restructuring in experimental local ischemia of different severity in the rat sensorimotor cortex.

Local cerebrovascular disorders were modeled by reversible photochemical clotting of hemispheric cortical vessels. Mild ischemia led to reversible edema in the surface layers of the cortex: cytotoxic edema of the neuropile, primarily of the distal dendrites. This status led to an increase in the lower delta rhythm frequency band power.

Structural changes in dendritic loci and protective effect of neurotrophic factors from the cerebral cortex of animals with favorable outcome of experimental hemorrhagic stroke.

Structural changes in the sensorimotor cortex of the cerebral hemispheres were studied in rats with experimental hemorrhagic stroke in the internal capsule. Changes in the shape and decrease in the density distribution of spines on apical dendrites of layer V pyramidal neurons of the sensorimotor cortex were revealed. Some fractions isolated from the complex of neurotrophic factors of the cerebral cortex of animals with a favorable outcome of hemorrhagic stroke were shown to affect the distal and proximal dendritic loci.

[Influence of carbon dioxide on the impregnation of the nervous tissue by silver].

It has been shown that 4% carbon dioxide (CO2) in the air above reaction mixture inhibits the initiation of the formation of silver nanoparticles from complexes with biogenic amines (noradrenaline and serotonin). At the same concentration of CO2 in the air above solution of AgNO3, which is used for staining nerve tissues by the method of Golgi, neurons are preferentially stained, whereas at a concentration of 0.06%, vessels and poor neurons are stained.

Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway.

The S6 kinases (S6Ks) have been linked to a number of cellular processes, including translation, insulin metabolism, cell survival, and RNA splicing. Signaling via the phosphotidylinositol 3-kinase and mammalian target of rapamycin (mTOR) pathways is critical in regulating the activity and subcellular localization of S6Ks. To date, nuclear functions of both S6K isoforms, S6K1 and S6K2, are not well understood.

Generation of monoclonal antibody targeting fibroblast growth factor receptor 3.

Fibroblast growth factor receptor 3 (FGFR3) is a member of the FGFR family of receptor tyrosine kinases, whose function has been implicated in diverse biological processes, including cell proliferation, differentiation, survival, and tumorigenesis. Deregulation of FGFR3 signaling has been implicated with human pathologies, including cancer. Activating mutations in FGFR3 gene are frequently detected in bladder cancer, multiple myeloma, and noninvasive papillary urothelial cell carcinomas, while the overexpression of the receptor is observed in thyroid lymphoma and bladder cancer.

Monoclonal antibodies with selective specificity towards different glycosylation isoforms of FGFR1.

Fibroblast growth factor receptor 1 (FGFR1) is a member of the FGFR family of receptor tyrosine kinases, whose function has been implicated in diverse biological processes including cell proliferation, differentiation, survival, and tumorigenesis. This diversity is possibly mediated by the existence of multiple FGFR1 isoforms, generated by alternative splicing and post-translational modifications, mainly through glycosylation. In this study we report the generation and characterization of a panel of monoclonal antibodies directed towards FGFR1.

Ultrastructural changes in the epithelium in asthma associated with gastroesophageal reflux.

Asthma concomitant with gastroesophageal reflux is regarded in the context of systemic multifactorial primary degenerative process, based on discoordination of neurohormonal regulation and systemic metabolic and degenerative changes. Degeneration and atrophy of the structural components of the bronchial tree and gastric wall are the leading phenomenons determining the organ dysfunction.

Structural modifications of the bronchial epithelium in asthma.

A complex of structural changes in the parenchymatous and stromal compartments, characteristic of the primary degenerative process (bronchial epithelium degeneration and subsequent diffuse atrophy, reactive sclerosis of the stroma) develops in the large bronchi in asthma. Induction of the regeneratory reactions of the bronchial epithelium with synchronously developing reorganization of the stroma (loosening of the connective tissue and stimulation of its vascularization) is shown during correction of asthma. Association of positive structural changes with lymphoid tissue hyperplasia in the bronchial wall can be interpreted in the context of significant role of lymphocytes in induction of the regeneratory reactions.

[Isolation of highly purified cyclodextrin glucanotransferase from Bacillus sp. 1070].

Two chromatographic processes for purification of cyclodextringlucanotransferase (CGTase) from Bacillus sp. 1070 was carried out. The enzyme has been purified into 9.