Blood flow dynamics in the arterial and venous parts of the capillary.

Although there is currently sufficient information on various parameters of capillary blood flow, including the average values of blood velocity, there is no data on the dynamics of velocity and the mechanisms of its modulation in various parts of the capillary. The main idea of this work is to develop a tool and image data processing to study the characteristics of the capillary blood flow dynamics. In this study, using the developed method of high-speed videocapillaroscopy, the red blood cells (RBC) velocities in the arterial and venous parts of the nailfold capillaries were compared and a time-frequency analysis of the dynamics of the velocity signals with the calculation of phase coherence was performed.

Navigating a Fine Balance: Point-Mutant Cheater Viruses Disrupt the Viral Replication Cycle.

Cheater viruses cannot replicate on their own yet replicate faster than the wild type (WT) when the 2 viruses coinfect the same cell. Cheaters must possess dual genetic features: a defect, which leads to their inability to infect cells on their own, and a selective advantage over WT during coinfection. Previously, we have discovered 2 point-mutant cheaters of the MS2 bacteriophage.

Odd-Numbered Ring Cluster Tc(μ-O)Cl(OOCCCl): Synthesis, Crystal Structure, and Optical and Thermal Properties.

Herein, we report a method for the preparation of the first odd homometallic and heterovalent nine-centered Tc wheel, [Tc(μ-O)Cl(OOCCl)]. The synthesized compound represents the pioneering instance of such clusters among d elements and is the fourth instance observed across all metals. The ring was synthesized by a solvothermal method in a solution of technetium acid in trichloroacetic anhydride.

Black Holes with Electroweak Hair.

We construct static and axially symmetric magnetically charged hairy black holes in the gravity-coupled Weinberg-Salam theory. Large black holes merge with the Reissner-Nordström (RN) family, while the small ones are extremal and support a hair in the form of a ring-shaped electroweak condensate carrying superconducting W currents and up to 22% of the total magnetic charge. The extremal solutions are asymptotically RN with a mass below the total charge, M<|Q|, due to the negative Zeeman energy of the condensate interacting with the black hole magnetic field.

Long term durability of Tc-bulk and Tc-coatings in various environmental conditions.

Technetium metal is renowned for its inertness in environmental conditions, rendering it an optimal candidate for use as a container material for high-level radioactive waste. Alternatively, thin technetium electroplated coatings can be employed to prevent corrosion of steel containers and the subsequent biofouling that may result. The utilization of metallic technetium in the design of containers for radioactive waste in deep burial may be promising from two perspectives: firstly, in terms of increasing their stability, and secondly, in terms of the utilization of technetium, which is a macrocomponent of radioactive waste.

Photoisomerization of two 2-hydroxy-5-arylazobenzaldehydes in solvents of different polarities.

Two azo dyes 2-hydroxy-5-(4-nitrophenylazo)benzaldehyde and 2-hydroxy-5-(4-chlorophenylazo)benzaldehyde dissolved in carbon tetrachloride, hexane, acetone and acetonitrile were irradiated with 365 nm UV light, and processes, occurring in them, were studied by NMR and UV-vis spectroscopy. It was established that reversible trans/cis photoisomerization of the molecules occurs in the non-polar solvents and is not observed in the polar solvents. 2D NOESY NMR spectroscopy was used to identify isomers of the azo compounds.

Photoplethysmography-Based Angiography of Skin Tumors in Arbitrary Areas of Human Body.

Noninvasive, rapid, and robust diagnostic techniques for clinical screening of tumors located in arbitrary areas of the human body are in demand. To address this challenge, we analyzed the feasibility of photoplethysmography-based angiography for assessing vascular structures within malignant and benign tumors. The proposed hardware and software were approved in a clinical study involving 30 patients with tumors located in the legs, torso, arms, and head.

New Perspectives in Colorectal Cancers Treatment, the Role of MicroRNAs.

The main epidemiological and clinical data on colorectal cancer, as well as the features of molecular pathology, are discussed in the literature review. Efforts are being putto identify promising targets, particularly small non-coding nucleotide sequences, which can lead to new treatments for this disease. The discovery of significant mutations that contribute to the development of colorectal tumors is a major step in the advancement of molecular oncology, as these mutations give rise to heterogeneous tumors that differ in their origin.

Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response.

Objective: Gut-residing bacteria, such as , can acetylate their proteome under conditions of amine starvation. It is postulated that the (gut) microbiome is involved in the breach of immune tolerance to modified self-proteins leading to the anti-modified protein antibodies (AMPAs), hallmarking seropositive rheumatoid arthritis (RA). Our aim was to determine whether acetylated bacterial proteins can induce AMPA responses cross-reactive to modified self-proteins and be recognised by human AMPA (hAMPA).

Synthesis of Technetium Carboxylates: Wheel-Like Octanuclear Clusters (Tc(μ-O)(RCOO), Where R = CF, CH)─Potential Nanobuilding Units for Tc-MOFs.

Herein, we studied the behavior of TcO in trifluoroacetic anhydride (TFAA) under visible light irradiation in situ by UV-vis spectroscopy. One carboxylate of Tc(VII) CFOTc () and two wheel-like carboxylate clusters of Tc(IV) Tc(μ-O)(CFCOO) (, ) and Tc(μ-O)(CHCOO) () were synthesized and analyzed using pXRD, TGA, UV-vis spectroscopy, and SCXRD techniques. According to SCXRD, it was found that Tc(IV) trifluoroacetate exists in two crystalline modifications.

Self-assessment of somatic and mental health by instructor-officers under the influence of negative factors of professional activities.

Objective: Aim: To investigate the impact of negative factors of professional activities in the context of the COVID-19 pandemic and martial law in Ukraine on the somatic and mental health of instructor-officers with different teaching experiences.

Patients And Methods: Materials and Methods: The research involved 131 instructor-officers with different teaching experiences. Three groups of instructor-officers were formed: Group 1 - instructors with up to 10 years of teaching experience (n = 30), Group 2 - instructors with 10 to 20 years of experience (n = 47), Group 3 - instructors with more than 20 years of experience (n = 54).

Vascular targeted optical theranostics: enhanced photoplethysmography imaging of laser-induced singlet oxygen effects.

The work considers a theranostic system that implements a multimodal approach allowing the simultaneous generation of singlet oxygen and visualization of the various parameters of the vascular bed. The system, together with the developed data processing algorithm, has the ability to assess architectural changes in the vascular network and its blood supply, as well as to identify periodic signal changes associated with mechanisms of blood flow oscillation of various natures. The use of this system seems promising in studying the effect of laser-induced singlet oxygen on the state of the vascular bed, as well as within the framework of the theranostic concept of treatment and diagnosis of oncological diseases and non-oncological vascular anomalies.

Femtosecond electron beam probe of ultrafast electronics.

The need for ever-faster information processing requires exceptionally small devices that operate at frequencies approaching the terahertz and petahertz regimes. For the diagnostics of such devices, researchers need a spatiotemporal tool that surpasses the device under test in speed and spatial resolution. Consequently, such a tool cannot be provided by electronics itself.

Targeted Sequencing in Gastric Cancer: Association with Tumor Molecular Characteristics and FLOT Therapy Effectiveness.

Heterogeneity of gastric cancer (GC) is the main trigger of the disease's relapse. The aim of this study was to investigate the connections between targeted genes, cancer clinical features, and the effectiveness of FLOT chemotherapy. Twenty-one patients with gastric cancers (GCs) were included in this study.

Compact realization of all-attosecond pump-probe spectroscopy.

The ability to perform attosecond-pump attosecond-probe spectroscopy (APAPS) is a longstanding goal in ultrafast science. While first pioneering experiments demonstrated the feasibility of APAPS, the low repetition rates (10 to 120 Hz) and the large footprints of existing setups have so far hindered the widespread exploitation of APAPS. Here, we demonstrate two-color APAPS using a commercial laser system at 1 kHz, straightforward post-compression in a hollow-core fiber, and a compact high-harmonic generation (HHG) setup.

Influence of the organic cation on the formation of hexahalotechnetates: X-ray, thermal and comparative analyses of non-covalent interactions.

In this work, we have reviewed non-covalent interactions in technetium hexahalide compounds and obtained eight new compounds of the CatTcHal type, where Cat = dimethylammonium, tetramethylammonium, caffeinium, benzothiazolium, nicotinamidium, and pyrazolium, and Hal = Cl, Br. SCXRD studies were carried out for new compounds. In some compounds, halide anions and/or crystallization water were present.

Route to Stabilization of Nanotechnetium in an Amorphous Carbon Matrix: Preparative Methods, XAFS Evidence, and Electrochemical Studies.

Technetium-carbon nanophases are obtained by thermal decomposition of pertechnetates with large organic cations under an argon atmosphere. Parallel carbonization of organic cations (hexamethyleneiminium and triphenylguanidinium), which occurs during the thermal decomposition of their pertechnetates, leads to the formation of X-ray amorphous solid products. An X-ray absorption fine structure study revealed that they have a crystal structure containing technetium-carbon bonds with a length of 1.

Relationships between xylem embolism and tree functioning during drought, recovery, and recurring drought in Aleppo pine.

Recent findings suggest that trees can survive high levels of drought-induced xylem embolism. In many cases, the embolism is irreversible and, therefore, can potentially affect post-drought recovery and tree function under recurring droughts. We examined the development of embolism in potted Aleppo pines, a common species in hot, dry Mediterranean habitats.

Intramolecular Re···O Nonvalent Interactions as a Stabilizer of the Polyoxorhenate(VII).

The first polyoxorhenate(VII) compound, pyrazolium polyoxorhenate ((CNH)ReO), and two new rhenium(VII) and technetium(VII) salts have been synthesized and studied. The structure of TcO has been reinvestigated. The [ReO] polyoxoanion contains four Re(VII) atoms: one with an octahedral environment and three with a tetrahedral environment.

First steps in the development of next-generation chirped volume Bragg gratings by means of fs laser inscription in fused silica.

The first steps towards the development and characterization of next-generation chirped volume Bragg gratings (CVBGs) by means of fs laser inscription were made. Based on the phase mask inscription technique we realized CVBGs in fused silica with a 3 × 3 mm aperture and a length of almost 12 mm with a chirp rate of ∼190 ps/nm around a central wavelength of 1030.5 nm.

New Preparative Approach to Purer Technetium-99 Samples-Tetramethylammonium Pertechnetate: Deep Understanding and Application of Crystal Structure, Solubility, and Its Conversion to Technetium Zero Valent Matrix.

Tc is one of the predominant fission products of U and an important component of nuclear industry wastes. The long half-life and specific activity of Tc (212,000 y, 0.63 GBq g) makes Tc a hazardous material.

Photoisomerization of 1,2-Di(4-pyridyl)ethylene According to NMR and UV Spectroscopy Data and Density Functional Modeling.

Photoisomerization of 1,2-di(4-pyridyl)ethylene under UV irradiation was studied by NMR and UV spectroscopy in solutions of acetone, acetonitrile and chloroform. It has been established that in the studied solutions under irradiation, geometric photoisomerization occurs: the trans-isomer transforms into the cis-isomer and then cyclization occurs. DFT modeling of the listed processes, states and UV absorption spectra of the sample in an acetonitrile solution was performed.

Thiourea as a Stabilizer of Reduced Forms of Technetium─Tc(III) and Tc(IV): Experimental and Theoretical Studies of Complexes.

This paper presents synthetic methods for the preparation of Tc(III) and Tc(IV) coordination compounds with thiourea. We have shown that the main product of the synthesis is the complex [TcTuX]X, (Tu = (NH)CS, X = Cl, Br) and not [TcTu]Cl·4HO, as previously thought. Tu[TcX]X·3HO is the main technetium-containing byproduct of the reaction.

IgG Fab Glycans Hinder FcRn-Mediated Placental Transport.

Abs can be glycosylated in both their Fc and Fab regions with marked effects on Ab function and binding. High levels of IgG Fab glycosylation are associated with malignant and autoimmune conditions, exemplified by rheumatoid arthritis and highly Fab-glycosylated (∼90%) anti-citrullinated protein Abs (ACPAs). Important properties of IgG, such as long half-life and placental transport, are facilitated by the human neonatal Fc receptor (hFcRn).

Optical transparency and label-free vessel imaging of zebrafish larvae in shortwave infrared range as a tool for prolonged studying of cardiovascular system development.

Optical techniques are utilized for the non-invasive analysis of the zebrafish cardiovascular system at early developmental stages. Being based mainly on conventional optical microscopy components and image sensors, the wavelength range of the collected and analyzed light is not out of the scope of 400-900 nm. In this paper, we compared the non-invasive optical approaches utilizing visible and near infrared range (VISNIR) 400-1000 and the shortwave infrared range (SWIR) 900-1700 nm.