[Effect of colchamine on Ehrlich ascitic carcinoma cells showing synchronized cell division].

The author studied the 24-hour changes in the number of normal and colchamine mitoses in the cells of Ehrlich's ascites carcinoma in mice after the injection of colchamine argainst the background of partial synchronization of cell division, obtained as a result of preliminary injection of dibutyryl cyclic 3',5'-AMP, and also in mice after the injection of colchamine alone or dibutyryl cyclic 3',5'-AMP. As shown, synchronization of cell division in the tumour led to the 2,6-fold increase in the number of tumour cells blocked by colchamine and also to the accelerated arrest of colchamine mitoses.

[Study of the effect of cAMP on the mitotic regimen in the esophageal epithelium of tumor-bearing mice].

The mitotic activity and number of DNA-synthesizing cells in the epithelium of the esophagus of the tumour-bearing albino mice were studied for 24 hours after the injection of dibutyryl cyclic 3', 5'-AMP. It was shown that injection of the preparation led to the blocking of cells in the G2-phase of the mitotic cycle, and to prolongation of mitosis during the first hours of the experiment without changing the total number of cells undergoing mitosis in the course of 24 hours.

[Changes in the body's oxygen regime in hypothalamic syndromes under the influence of hypoxic mixtures].

A study of the oxygen regimen in the organism of patients with hypothalamic syndromes (vegetative, vascular and neuroendrocrino-metabolic) according to the Lauer and Kolchinskaya method demonstrated that an inhalation of hypoxic mixture containing 15% of oxygen leads to changes in the respiration indices. Such changes were related to circulation, oxygen parameters and indicated an increase of hypoxemia under the influence of this mixture and of a significant drop in the consumption of oxygen by the tissues. This may also speak in favour of an inhibition of activities in the compensatory and adaptational mechanisms.

[The synchronizing effect of cyclic 3',5'-adenosine monophosphate on the mitotic cycle of Ehrlich ascitic carcinoma cells].

A study was made of the number of mitoses and of the DNA-synthesizing cells in the ascitic Ehrlich carcinoma in the course of 24 hours after the injection of cyclic 3',5'-adenosinmonophosphate to mice. It was found that as the result of the preprrophase inhibition and, possibly, of stimulation of the cell entry into the S-phase, 8 hours after the action a great number of cells began to divide almost simultaneously. The effect of mitosis synchronization was assessed in the tumour cell population.