Evaluation of Hypersensitivity Reactions in Pediatric Patients Using Biological Drugs.

Introduction: Biological drugs are currently used for the treatment of chronic inflammatory, autoimmune, and neoplastic diseases. With their expanding indication spectrum and increasing use, hypersensitivity reactions to these drugs are also becoming more frequent. The present study aimed to report the incidence and the features of such reactions in pediatric patients using biologicals for the treatment of various diseases.

The impact of pretreatment serum cobalamin and folate levels on complications and peripheral blood recovery during induction chemotherapy of leukemia: a cross-sectional study.

Objectives: We aimed to evaluate the impact of pretreatment folate and vitamin B deficiencies on the frequency of complications and peripheral blood recovery, in children with acute lymphoblastic leukemia (ALL).

Methods: Pre-induction serum folate and vitamin B levels of 88 newly diagnosed ALL patients were evaluated retrospectively. Folate < 3 ng/mL and vitamin B < 200 pg/mL were accepted as deficiency.