Assessing the Outputs, Outcomes, and Impacts of Science Communication: A Quantitative Content Analysis of 128 Science Communication Projects.

Few studies have explored how science communication projects are evaluated and what impact they have. This study aims to fill this gap by analyzing the results of science communication projects carried out by academics. Drawing on the theory of change and evaluation models, possible results of science communication projects are conceptually distinguished at the levels of outputs, outcomes, and impacts.

Prognostic and therapeutic implications of tumor-restrictive type III collagen in the breast cancer microenvironment.

Collagen plays a critical role in regulating breast cancer progression and therapeutic resistance. An improved understanding of both the features and drivers of tumor-permissive and -restrictive collagen matrices are critical to improve prognostication and develop more effective therapeutic strategies. In this study, using a combination of in vitro, in vivo and bioinformatic experiments, we show that type III collagen (Col3) plays a tumor-restrictive role in human breast cancer.

How generative artificial intelligence portrays science: Interviewing ChatGPT from the perspective of different audience segments.

Generative artificial intelligence in general and ChatGPT in particular have risen in importance. ChatGPT is widely known and used increasingly as an information source for different topics, including science. It is therefore relevant to examine how ChatGPT portrays science and science-related issues.

Videodistraction to reduce agitation in elderly patients in the emergency department: an open label parallel group randomized controlled trial.

Background And Importance: Agitation of elderly patients in the emergency department (ED) often complicates workup and therapy.

Objective: In this study, we investigated if agitation in the ED can be reduced by showing calming video sequences in elderly agitated patients.

Designs: Prospective randomized intervention study.

Structural Ordering in Ultrasmall Multicomponent Chalcogenides: The Case of Quaternary Cu-Zn-In-Se Nanocrystals.

The compositional tunability of non-isovalent multicomponent chalcogenide thin films and the extent of atomic ordering of their crystal structure is key to the performance of many modern technologies. In contrast, the effects of ordering are rarely studied for quantum-confined materials, such as colloidal nanocrystals. In this paper, the possibilities around composition tunability and atomic ordering are explored in ultrasmall ternary and quaternary quantum dots, taking I-III-VI-group Cu-Zn-In-Se semiconductor as a case study.

The plurivocal university: Typologizing the diverse voices of a research university on social media.

Science communication has diversified in the wake of the digital transformation of communication and media ecosystems. Social media enable universities, but also academics and institutions affiliated with them, to expand their communication. This leads to increasing plurivocality of universities, yet the many different voices remain largely unexplored.

Combining antibiotic with anti-TLR2/TLR13 therapy prevents brain pathology in pneumococcal meningitis.

Despite effective antibiotic therapy, brain-destructive inflammation often cannot be avoided in pneumococcal meningitis. The causative signals are mediated predominantly through TLR-recruited myeloid differentiation primary response adaptor 88 (MyD88), as indicated by a dramatic pneumococcal meningitis phenotype of Myd88-/- mice. Because lipoproteins and single-stranded RNA are crucial for recognition of Gram-positive bacteria such as Streptococcus pneumoniae by the host immune system, we comparatively analyzed the disease courses of Myd88-/- and Tlr2-/- Tlr13-/- mice.

Use of Postoperative Opioid Therapy Following Endoscopic Sleeve Gastroplasty.

Introduction: There are no established guidelines on periprocedural and postprocedural pain management after endoscopic sleeve gastroplasty (ESG). This study aimed to determine the need for perioperative and postoperative opioid therapy in patients undergoing ESG.

Methods: This retrospective study comprised consecutive patients undergoing ESG.

Use of Impedance Planimetry in the Diagnosis of Gastric Sleeve Stenosis: The Establishment of New Benchmark Values.

Introduction: Gastric sleeve stenosis (GSS) is an increasingly common adverse event following sleeve gastrectomy for which objective diagnostic criteria are lacking. Impedance planimetry measurements show promise in characterizing GSS, though normal and abnormal benchmark values have never been established.

Methods: This was a retrospective analysis of upper endoscopies performed with impedance planimetry for suspected GSS.

A prospective longitudinal cohort study on risk factors for COVID-19 vaccination failure (RisCoin): methods, procedures and characterization of the cohort.

The primary objective of the RisCoin study was to investigate the interplay of genetic, metabolic, and lifestyle factors as well as stress levels on influencing the humoral immune response after at least two COVID-19 vaccinations, primarily with mRNAs, and the risk of SARS-CoV-2 breakthrough infections during follow-up. Here, we describe the study design, procedures, and study population. RisCoin is a prospective, monocentric, longitudinal, observational cohort study.

Tumor-restrictive type III collagen in the breast cancer microenvironment: prognostic and therapeutic implications.

Collagen plays a critical role in regulating breast cancer progression and therapeutic resistance. An improved understanding of both the features and drivers of tumor-permissive and -restrictive collagen matrices are critical to improve prognostication and develop more effective therapeutic strategies. In this study, using a combination of experiments, we show that type III collagen (Col3) plays a tumor-restrictive role in human breast cancer.

Endoscopic severity of gastric sleeve stenosis can be quantified using impedance planimetry.

Background: Gastric sleeve stenosis (GSS) is an adverse event following sleeve gastrectomy for which objective tools are needed for diagnosis and treatment. Endoscopic treatment with serial pneumatic balloon dilation may relieve symptoms and prevent the need for conversion to Roux-en-Y gastric bypass. Endoluminal functional impedance planimetry (EndoFLIP) is an endoscopic tool that measures luminal diameter and distensibility indices (DI) and could be used to characterize severity of GSS.

Cerebrospinal fluid analysis in emergency patients with suspected infection of the central nervous system.

Background And Purpose: Meningitis and encephalitis are potentially life-threatening diseases that require fast and accurate diagnostics and therapy. The value of polymerase chain reaction (PCR) multiplex testing in clinical practice is still a matter of debate. This study aims to evaluate its benefits and limitations in emergency patients.

Patient disposition using the Emergency Severity Index: a retrospective observational study at an interdisciplinary emergency department.

Objectives: Early patient disposition is crucial to prevent crowding in emergency departments (EDs). Our study aimed to characterise the need of in-house resources for patients treated in the ED according to the Emergency Severity Index (ESI) and the presenting complaint at the timepoint of triage.

Design: A retrospective single-centre study was conducted.

Pneumatic Balloon Dilation of Gastric Sleeve Stenosis Is Not Associated with Weight Regain.

Background: Gastric sleeve stenosis (GSS) occurs in up to 4% of patients after laparoscopic sleeve gastrectomy (LSG). Typical symptoms include reflux, abdominal pain, dysphagia, and regurgitation. Serial pneumatic balloon dilation (PBD) is a successful treatment in many cases obviating the need for revisional surgery, but the potential for weight regain is unknown.

Cysteine-rich domain of type III collagen N-propeptide inhibits fibroblast activation by attenuating TGFβ signaling.

TGFβ is a key regulator of the dynamic reciprocity between cells and the extracellular matrix that drives physiologic and pathologic responses in both tissue repair and tumor microenvironments. Our studies define type III Collagen (Col3) as a suppressor of scar formation and desmoplasia through its effects, in part, on myofibroblasts. TGFβ stimulates activation of myofibroblasts, and here, we demonstrate that cultured Col3-deficient fibroblasts have increased TGFβ signaling compared to wild-type fibroblasts.

Decline in the number of patients with meningitis in German hospitals during the COVID-19 pandemic.

Background And Objectives: In 2020, a wide range of hygiene measures was implemented to mitigate infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In consequence, pulmonary infections due to other respiratory pathogens also decreased. Here, we evaluated the number of bacterial and viral meningitis and encephalitis cases during the coronavirus disease 2019 (COVID-19) pandemic.

Cell Therapy in Veterinary Medicine as a Proof-of-Concept for Human Therapies: Perspectives From the North American Veterinary Regenerative Medicine Association.

In the past decade, the potential to translate scientific discoveries in the area of regenerative therapeutics in veterinary species to novel, effective human therapies has gained interest from the scientific and public domains. Translational research using a One Health approach provides a fundamental link between basic biomedical research and medical clinical practice, with the goal of developing strategies for curing or preventing disease and ameliorating pain and suffering in companion animals and humans alike. Veterinary clinical trials in client-owned companion animals affected with naturally occurring, spontaneous disease can inform human clinical trials and significantly improve their outcomes.

Impact of Feeding Syngenta Enogen Feed Corn Compared to Control Corn in Different Diet Scenarios to Finishing Beef Cattle.

The objective of this pooled statistical analysis was to evaluate Syngenta Enogen Feed Corn (EFC) versus conventional corn (CON) when fed as either dry-rolled corn (DRC) or high-moisture corn (HMC) for effects on finishing beef cattle performance and carcass characteristics. Corns were evaluated in diets with byproduct inclusion rates of 0, 15, 18, 20, and 30% distiller grains or 25 and 35% Sweet Bran (a commercial corn gluten feed product). Seven trials ( = 1856) consisting of 200 pen means comparing 26 diet treatments were analyzed using regression in a pooled analysis.