PROSPECTS FOR CREATION OF RADIOPROTECTIVE MEANS BASED ON NATURAL POLYPHENOLS AND POLYSACCHARIDES.

Unlabelled: The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation. Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers.

Objective: Justification of the prospects of creating radioprotective agents based on compositions of plantpolyphenolic substances (PPS) and polysaccharides.

[The regulation of the composition of commercial forms of pesticides and the principles for evaluating their toxicity and hazards].

On the basis of data analysis on harmful effect of components of the trade forms of pesticides (pesticides, emulsifying agents, solvents, etc.) it is suggested to consider them as combined preparations. Their toxicity and danger assessment principles are formulated.

[Blood coagulating and anticoagulant properties of the tissues in experimental chronic alcoholism in albino rats].

A study was made of thromboplastin, antiheparin and antithrombin activity of the brain, heart and liver tissues of rats in experimental chronic alcoholization. Appreciable changes in the tissue factors of coagulation according to the dyscoagulemia type depending on the duration and gravity of alcoholic intoxication may aggravate hemostatic disorders.

[The use of a solution of quercetin for the treatment of inflammatory diseases of the parotid glands].

The possibility to use 0.1% quercetin solution for the treatment of inflammatory diseases of the parotid glands was studied. The effectiveness of treatment of 26 patients was estimated according to the data of clinical examination and cytologic study of the saliva.

[Use of stachyrene in combined treatment of patients with obstructive jaundice].

In 49 patients with obstructive jaundice of various genesis progressive cholemic intoxication in absence of the effect from conventional detoxication therapy, the Stachyrene preparation, which contains as an effective agent the polyphenol compounds of Stachys recta L., was used. Stachyrene was administered before and after the operation.

[The use of quercetin granules for treating suppurative soft-tissue wounds of the maxillofacial area and neck].

Wound-healing effect of quercetin granules was examined in 20 experimental animals and in 90 patients with suppurative-inflammatory diseases of the maxillofacial and cervical soft tissue. The results evidence anti-inflammatory and wound-healing effects of quercetin granules used as 20% gel.

[The effect of para-aminomethylbenzoic acid (amben) on peripheral nerve regeneration].

Various injuries to the sciatic nerve were modelled in experiments on 60 rats and 27 dogs to study the effect of paraaminomethylbenzoic acid on its regeneration; the efficacy of amben was compared with that of other agents used widely for the treatment of injuries to nerves. It was found that amben acts on the connective tissue of the neural scar and creates favourable conditions for growth of axons from the central to the peripheral stump of the injured nerve and accelerated their maturation.

[Bile secretion in dogs after intravenous administration of glucose].

The effect of drop infusions of 10% glucose solution for parenteral nutrition, in a dose of 2 g/kg, on bile secretion was studied in experiments on dogs with chronic gallbladder-duodenal fistulas. It was demonstrated that the infusion of hypertonic glucose solution inhibits bile production quantitatively and qualitatively.