Are professional road cycling countries selecting their talents based on anthropometric characteristics which suit the countries' terrain?

Background: This study investigates if countries are more focused on certain specializations (one day, climb, sprint, time trial [TT] and grand tour [GC]) in male professional road cycling and if this is possibly linked to the countries landscape (for example, does a mountainous country have more climbers?) and anthropometric characteristics (does the mountainous country also have lighter cyclists?) of their cyclists.

Methods: Body weight, height, procyclingstats (PCS) points per specialty were gathered from 1810 professional cyclists out of 15 countries, as well as the elevation span of those countries. To compare the anthropometric differences between different countries, height was normalized based on the average height of the countries' population, while BMI was used as a correction for body weight.

Durability and Underlying Physiological Factors: How Do They Change Throughout a Cycling Season in Semiprofessional Cyclists?

Purpose: To investigate how cycling time-trial (TT) performance changes over a cycling season, both in a "fresh" state and in a "fatigued" state (durability). Additionally, the aim was to explore whether these changes are related to changes in underlying physiological factors such as gross efficiency, energy expenditure (EE), and substrate oxidation (fat oxidation [FatOx] and carbohydrate oxidation [CarbOx]).

Methods: Sixteen male semiprofessional cyclists visited the laboratory on 3 occasions during a cycling season (PRE, START, and IN) and underwent a performance test in both fresh and fatigued states (after 38.

Targeted Inhibition of CYP11A1 in Castration-Resistant Prostate Cancer.

BACKGROUND: Prostate cancer is regulated by steroid hormones, even in castration-resistant disease. ODM-208, a novel inhibitor of cytochrome P450 11A1 (which catalyzes the first step of steroid-hormone biosynthesis), was investigated in patients with heavily pretreated metastatic castration-resistant prostate cancer (mCRPC). METHODS: CYPIDES is a first-in-human phase 1 (3 + 3 design) and phase 2 study.

Association between baseline meniscal extrusion and long-term incident knee osteoarthritis in two different cohorts.

Objective: Previously, we identified a significant association between meniscal extrusion and short-term incident knee osteoarthritis (KOA). To validate these findings, we evaluated long-term incident KOA in knees with meniscus extrusion, using two different cohorts.

Methods: We used data from the PROOF study, which evaluated a high-risk population of overweight women, and a female subcohort of the population-based Rotterdam Study (RS).

The role of the relative age effect on talent identification in professional road cycling.

This study aims to investigate the presence of the relative age effect (RAE) in (semi-)professional cycling, especially within selecting cyclists for Continental (CT) development teams. Data were collected from www.procyclingstats.

Multi-territory stroke preceded by pulmonary embolism with asymptomatic coronavirus disease 2019: a case report.

Background: Non-bacterial thrombotic endocarditis is characterized by the presence of sterile vegetations on a cardiac valve. We present a case of multi-territory stroke caused by embolism of a non-bacterial thrombotic aortic valve endocarditis, leading to the diagnosis of a prostate adenocarcinoma with bone metastases.

Case Summary: A 66-year-old patient was diagnosed with pulmonary embolism, first attributed to an asymptomatic coronavirus disease 2019 infection.

Are changes in meniscus volume and extrusion associated to knee osteoarthritis development? A structural equation model.

Objective: To explore the interplay between (changes in) medial meniscus volume, meniscus extrusion and radiographic knee osteoarthritis (OA) development over 30 months follow-up (FU).

Methods: Data from the PRevention of knee Osteoarthritis in Overweight Females study were used. This cohort included 407 middle-aged women with a body mass index ≥27 kg/m, who were free of knee OA at baseline.

Policy preferences in response to negative economic prospects of COVID-19: A survey-experiment among local politicians in four European countries.

This study investigates how the negative economic prospects of the COVID-19 pandemic affect local government politicians' policy preferences in the Netherlands, the United Kingdom, Switzerland, and Spain. The study examines to what extent politicians prefer increasing the role of government (directive state), transferring public tasks to private sector organizations (hollow state), transferring public tasks to third sector organizations (communitarian state), or downsizing and reducing the role of government without transferring tasks (coping state). The experiment primes decision-makers on the pandemic's negative financial and economic prospects vis-à-vis its impact on health and well-being.

Factors associated with longitudinal change of meniscal extrusion in overweight women without clinical signs of osteoarthritis.

Objectives: To identify variables associated with longitudinal change in meniscal extrusion, which might be used as possible targets for knee osteoarthritis (KOA) prevention.

Methods: In a high-risk population of middle-aged overweight women, meniscal extrusion was assessed with magnetic resonance imaging (1.5 T, coronal proton density, in-plane resolution 0.

Association between meniscal volume and development of knee osteoarthritis.

Objective: To assess the association between meniscal volume, its change over time and the development of knee OA after 30 months in overweight/obese women.

Methods: Data from the PRevention of knee Osteoarthritis in Overweight Females study were used. This cohort included 407 women with a BMI ≥ 27 kg/m2, free of OA-related symptoms.

Impact of different anticoagulation management strategies on outcomes in atrial fibrillation: Dutch and Belgian results from the GARFIELD-AF registry.

Background: The uptake rate of non-vitamin K oral anticoagulants (NOAC) for the treatment of non-valvular atrial fibrillation (AF) was far lower in the Netherlands (NL) compared to Belgium (BE). Also, patients on VKA in NL were treated with a higher target international normalized ratio (INR) range of 2.5 to 3.

What is the Preferred Screening Tool for COVID-19 in Asymptomatic Patients Undergoing a Surgical or Diagnostic Procedure?

Introduction: Since the outbreak of COVID-19, measures were taken to protect healthcare staff from infection, to prevent infection of patients admitted to the hospital and to distribute PPE according to need. To assure the proper protection without overuse of limited supply of these equipments, screening of patients before surgical or diagnostic procedure was implemented. This study evaluates the results of this screening.

Development of phenylthiourea derivatives as allosteric inhibitors of pyoverdine maturation enzyme PvdP tyrosinase.

Infections caused by Pseudomonas aeruginosa become increasingly difficult to treat because these bacteria have acquired various mechanisms for antibiotic resistance, which creates the need for mechanistically novel antibiotics. Such antibiotics might be developed by targeting enzymes involved in the iron uptake mechanism because iron is essential for bacterial survival. For P.

Undiagnosed adult congenital heart disease presenting with postpartum dyspnoea: a case report.

Patients with adult congenital heart disease are born with structural heart defects who survived into adulthood. Occasionally, complex lesions remain undiagnosed, potentially causing substantial cardiovascular health problems at young age. Here, the case is presented of a patient with subacute heart failure 1 week postpartum, revealing the diagnosis of aortic coarctation (CoA) with patent ductus arteriosus (PDA).

Feasibility and performance of a device for automatic self-detection of symptomatic acute coronary artery occlusion in outpatients with coronary artery disease: a multicentre observational study.

Background: Time delay between onset of symptoms and seeking medical attention is a major determinant of mortality and morbidity in patients with acute coronary artery occlusion. Response time might be reduced by reliable self-detection. We aimed to formally assess the proof-of-concept and accuracy of self-detection of acute coronary artery occlusion by patients during daily life situations and during the very early stages of acute coronary artery occlusion.

Treatment patterns in anticoagulant therapy in patients with newly diagnosed atrial fibrillation in Belgium: results from the GARFIELD-AF registry.

AF, anticoagulation, NOACs, changing patterns of prescription. We describe baseline data and treatment patterns of patients recruited in Belgium in the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF). Recruitment began when novel oral anticoagulants (NOACs) were introduced and provides a unique picture of changing treatment patterns over time.

Baseline meniscal extrusion associated with incident knee osteoarthritis after 30 months in overweight and obese women.

Objective: To investigate the association between baseline meniscal extrusion and the incidence of knee osteoarthritis (KOA) after 30 months in a high-risk population of overweight and obese women, free of clinical and radiological KOA at baseline.

Methods: 407 middle-aged overweight women (body mass index - BMI ≥ 27 kg/m) were evaluated at baseline and after 30 months of follow-up. Meniscal extrusion was defined as grade ≥2 on MRI according to MRI Osteoarthritis Knee Score (MOAKS).

Occurrence and point source characterization of perfluoroalkyl acids in sewage sludge.

The occurrence and levels of perfluoroalkyl acids (PFAAs) emitted from specific pollution sources into the aquatic environment in Switzerland were studied using digested sewage sludges from 45 wastewater treatment plants in catchments containing a wide range of potential industrial emitters. Concentrations of individual PFAAs show a high spatial and temporal variability, which infers different contributions from industrial technologies and activities. Perfluorooctane sulfonic acid (PFOS) was generally the predominant PFAA with concentrations varying between 4 and 2440μgkg(-1) (median 75μgkg(-1)).

Long-term outcome study in patients with abdominal wound dehiscence: a comparative study on quality of life, body image, and incisional hernia.

Objective: Long-term quality of life and body image of patients with abdominal wound dehiscence were assessed.

Methods: Thirty-seven patients with abdominal wound dehiscence from a prospectively followed cohort of 967 patients (2007-2009) were reviewed. Patients completed the Short Form 36 quality of life questionnaire and Body Image Questionnaire and participated in semi-structured telephone interviews.

Uptake and release kinetics of 22 polar organic chemicals in the Chemcatcher passive sampler.

The Chemcatcher passive sampler, which uses Empore™ disks as sampling phase, is frequently used to monitor polar organic chemicals in river water and effluents. Uptake kinetics need to be quantified to calculate time-weighted average concentrations from Chemcatcher field deployments. Information on release kinetics is needed if performance reference compounds (PRCs) are used to quantify the influence of environmental conditions on the uptake.

The mercury resistance (mer) operon in a marine gliding flavobacterium, Tenacibaculum discolor 9A5.

Genes conferring mercury resistance have been investigated in a variety of bacteria and archaea but not in bacteria of the phylum Bacteroidetes, despite their importance in many environments. We found, however, that a marine gliding Bacteroidetes species, Tenacibaculum discolor, was the predominant mercury-resistant bacterial taxon cultured from a salt marsh fertilized with mercury-contaminated sewage sludge. Here we report characterization of the mercuric reductase and the narrow-spectrum mercury resistance (mer) operon from one of these strains - T.