Hepatic arterial infusion for biliary tract carcinoma: single-center experience.

Aim: The aim of the present study was to evaluate a single-center experience in hepatic arterial infusion (HAI) of patients with biliary tract carcinomas.

Patients And Methods: A retrospective analysis of 60 patients treated between 1997 and 2011 was performed.

Results: Most patients were treated with HAI of a combination of 5-fluorouracil, folinic acid and cisplatin.

Hepatic arterial infusion of irinotecan, 5-Fluorouracil and leucovorin in patients with liver metastases from colorectal carcinoma.

Aim: The aim of the present study was to evaluate single center experience with hepatic arterial infusion (HAI) of irinotecan, 5-fluorouracil and leucovorin in patients with liver metastases from colorectal carcinoma (CRC).

Patients And Methods: A retrospective analysis of 68 patients treated between 1998 and 2007 was performed.

Results: Among 60 patients who had no simultaneous liver-directed procedure (LDP), the best results obtained were complete response in two patients (3%), partial response in 18 patients (30%), and stable disease in 23 patients (38%), for an overall disease control rate of 72%.

Liver metastases from uveal melanoma: clinical experience of hepatic arterial infusion of cisplatin, vinblastine and dacarbazine.

Background/aims: Liver is the most common site of metastases in uveal melanoma. Hepatic arterial infusion of cytotoxic agents may be an effective method of controlling the disease in these patients.

Methodology: A retrospective analysis of 10 patients with hepatic metastases of uveal melanoma treated with hepatic arterial infusion (HAI) of the combination of cisplatin, vinblastine and dacarbazine was performed.

[Bleeding from aortointestinal fistula].

Introduction: Aortointestinal fistula is a patological communication between the aorta and the gut. Two groups of these fistulas are described. The primary fistulas originated as complications of aneurysma of the abdominal aorta and the secondary fistulas as a consequence of reconstruction of the abdominal aorta or the iliac arteries.

Survival of patients with colorectal cancer liver metastases treated by regional chemotherapy.

Background/aims: Liver is the most common site of metastatic disease in colorectal cancer. Superior response rate was demonstrated in trials comparing hepatic arterial administration of cytotoxic agents with systemic chemotherapy.

Methodology: Records of 109 consecutive patients with colorectal carcinoma metastatic to the liver treated by regional chemotherapy, who underwent implantation of a port system into hepatic artery or portal vein tributaries between 1991 and 1999, were reviewed and survival was evaluated using the log-rank test and multivariate analysis (Cox's proportional hazard regression).

Regional chemotherapy in patients with breast carcinoma liver metastases.

Background/aims: Although liver is a common site of metastases in breast cancer, isolated liver metastases in patients with disseminated breast cancer are rare. The role of liver-directed therapies in these patients is based on data derived from retrospective analysis of case series.

Methodology: We have reviewed the records of 8 patients with liver metastases and a history of breast cancer treated at our institution over a period of 11 years with regional chemotherapy administered through surgically implanted port systems.

Pathological complete response in advanced gastrointestinal stromal tumor after imatinib therapy.

Gastrointestinal stromal tumor (GIST) is a rare neoplasm exhibiting, in most cases, mutations of c-kit. Recently it has been demonstrated that a majority of GIST patients with c-kit mutations respond to therapy with imatinib, a c-kit tyrosine kinase inhibitor. Although the response rate in patients treated with imatinib in prospective clinical studies is above 50%, complete response is rare, and the data on the use of imatinib as neoaduvant therapy facilitating radical surgery is still scanty.

Radio-guided sentinel node detection during the surgical treatment of rectal cancer.

Objective: The detection of sentinel nodes is performed in various types of malignant disease. The aim of this study was to evaluate the results of the radiodetection of sentinel nodes, based on the use of Tc-colloid, during the surgical treatment of rectal cancer.

Methods: In 2003-2004, 42 patients (24 males and 18 females; average ages of 62.

[Intraperitoneal placement of composite implants--polyester mesh coated with polyurethane in experimental study].

Introduction: Polyester and polypropylene are currently the most frequently materials for repair of abdominal wall hernias. Most of the mesh materials used intraperitoneally in repair of hernias lead to considerable adhesion formation, as well as the resultant bowel obstruction and intestinal fistula formation. Some newer composite products can reduce risk of adhesion formation.

Hepatic arterial infusion chemotherapy in sarcoma liver metastases: a report of 6 cases.

Aims And Background: Liver metastases in patients with sarcoma are rare and associated with a poor prognosis. The experience with liver-directed therapies, eg hepatic arterial infusion, in these patients is limited.

Methods: Six patients with sarcoma metastatic to the liver (4 patients with gastrointestinal stromal tumors and 2 patients with leiomyosarcoma) were treated by hepatic arterial infusion in our center over a 12-year period.

[Haemosuccus pancreaticus].

Haemosuccus pancreaticus is a rare cause of gastrointestinal bleeding. The blood is passing into the pancreatic duct through the route between an aneurysm of an artery close to the pancreas and pancreatic duct. The blood goes to the gastrointestinal system through Vater's papilla and the patient becomes anemic.

[Mesenchymal extraperitoneal tumors in the elderly].

Incidence rates of solid tumors increase with age in our population. Epithelial tumors are the most frequent tumors of the old age. On the contrary, extraperitoneal mesenchymal tumors are rare.

[Cooperation between a surgeon and an interventional radiologist in cases of internal bleeding].

Introduction: Internal bleeding still remains a serious condition, which must be urgently diagnosed and treated. In the Faculty Hospital in Hradec Králové the diagnosis of the internal bleeding source and its consequent treatment is managed under cooperation between a surgeon and an interventional radiologist. A CASE-REVIEW: In the case-review section of this report, a total number of five patients with serious cases of internal bleeding, the source of which was diagnosed and treated under cooperation between the above mentioned specialists is presented.

Hepatic arterial infusion chemotherapy in gastric cancer: a report of four cases and analysis of the literature.

Aims And Background: Gastric cancer is associated with high mortality. Although the liver is a common site of metastases in this tumor, the experience with liver-directed therapies is limited.

Methods: We report a single-center experience involving four patients with liver metastases from gastric cancer treated by hepatic arterial infusion (HAI).

Immunoscintigraphy and intra-operative radioimmunodetection in the treatment of colorectal carcinoma.

Purpose: Intra-operative radioimmunodetection of malignant involved lymph nodes follows the pre-operative immunoscintigraphy in the treatment of patients with colorectal carcinoma. The aims of this clinical study were to determine the sensitivity of the method, to compare the results in study when using Oncoscint and CEA-Scan and to evaluate the importance of the method of surgery and postoperative adjuvant therapy.

Patients And Methods: 121 patients with colorectal tumours (106 primary and 15 recurrent) were operated on using radioimmunoguided surgery (RIGS).

Hepatocellular carcinoma presenting with bone metastasis.

Bone metastasis is an unusual complication of hepatocellular carcinoma. We report here 2 cases of patients with bone metastases of hepatocellular carcinoma at presentation. Patient No.

Regional chemotherapy in biliary tract cancers--a single institution experience.

Background/aims: The prognosis of biliary tract cancers is poor. The aim of the present report was to analyze retrospectively the effectiveness of regional chemotherapy in patients with biliary tract cancers treated at a single institution.

Methodology: Thirty-two patients with biliary tract cancers, 17 patients with cholangiocarcinoma and 15 patients with gallbladder carcinoma, were treated by regional administration of the chemotherapy, usually the combination of 5-fluorouracil, cisplatin and folinic acid.

[Infectious aneurysm of the abdominal aorta caused by Salmonella: diagnosis, endovascular therapy].

The authors present a case of an infected abdominal aortic aneurysms by means of a minimally invasive endovascular method using a stent graft. This patient had already been treated by TIPS (transjugular intrahepatic portosystemic shunt) for repeated varicose bleeding due to liver cirrhosis. Standard surgical therapy of infected abdominal aneurysms and about advantages and possibilities of endovascular treatment with stent grafts are discussed.

Regional administration of irinotecan in combination with 5-fluorouracil and leucovorin in patients with colorectal cancer liver metastases--a pilot experience.

Background/aims: Regional chemotherapy represents an effective approach for the control of isolated liver metastases of colorectal cancer. Fluoropyrimidines have been the basis of systemic and regional chemotherapy of this disease for several decades, but recent studies have demonstrated that the addition of irinotecan (CPT-11) ameliorates the results of systemic treatment.

Methodology: Fifteen patients with isolated liver metastases of colorectal carcinoma were treated with regional administration of CPT-11 in combination with 5-fluorouracil/folinic acid (5-FU/FA).

Intraarterial chemotherapy of malignant melanoma metastatic to the liver.

Background/aims: The prognosis of malignant melanoma metastatic to the liver is poor. The aim of the present report was to analyze retrospectively the effectiveness of regional chemotherapy and biologic therapy in patients with hepatic metastases of malignant melanoma.

Methodology: Seven patients with hepatic metastases of malignant melanoma were treated by intraarterial administration of the combination of cisplatin, vinblastine and dacarbazine, or melphalan, with or without interleukin-2, interferon-alpha and interferon-gamma.

[The spiral Z-stent with a knit dacron coating in endoluminal therapy of aneurysms of the abdominal aorta].

The authors present their own experience with construction, experimental testing and clinical application of endoluminal grafts. In the first part of the project, a new selfexpandable stentgraft was constructed on the basis of spiral Z stent. Spiral Z stent was covered by ultrathin polyester sleeve.

[Subadventitial rupture of the internal carotid artery].

The author describes the case of a 21-year-old patient who contracted an injury of the internal carotid by collision with the tip of a metal rod. The injury led to the development of a sub-adventitial rupture of the carotid artery and its subsequent thrombosis. The patient was admitted to the Clinic 12 hours after he lost consciousness.