[Neurophysiological substantiation and validity assessment of manual muscle testing in clinical practice. (A literature review)].

The relevance of the study of neuromuscular dysfunction's causes and mechanisms is undeniable, considering the large number of nosologies accompanied by malfunction of muscles. Adequate diagnosis and correction of these disorders is impossible without understanding of their pathogenetic mechanisms. Currently, manual muscle testing (MMT) is a widespread technique.

Conformational Changes in DNA and Protein Biomolecules in Pathogenesis of Ischemic Stroke.

Conformational changes in DNA and protein biomolecules were studied in ischemic stroke (IS) cases varying severity by Raman spectroscopy. The conformational structure of hematoporphyrin was found to change in IS patients, leading to a higher (I/I)/(I/I) ratio (hemoglobin affinity of for ligands) and an increase in I/I (a change in pyrrole conformation). Changes in genomic DNA spectra were observed at frequencies caused by stretching vibrations of primary amines (3400 cm), secondary amines and hydroxyls involved in hydrogen bonding (3100 cm), and CH groups of sugar phosphates (2900 cm) and vibrations of vibrational bonds between nitrogenous bases and sugars (1400 cm).

[Predicting the course of urgent abdominal diseases based on intensity of catabolic phenomena].

Objective: To develop a highly informative method for predicting the course of early postoperative period in urgent abdominal surgery based on indicators of lipid metabolism.

Material And Methods: We analyzed 113 patients with acute surgical abdominal disease including 56 (49.6%) ones with acute appendicitis complicated by peritonitis, 23 (20.

[Renal distress syndrome in surgery and uronephrology: concept, pathogenesis, basics of prevention and correction].

Objective: Based on objective criteria of the structural and functional state of the kidneys in various urgent surgical and uronephrological pathologies (peritonitis, pancreonecrosis, intestinal obstruction, urinary peritonitis, acute purulent secondary pyelonephritis) to identify and prove the general pattern of development of renal changes, their influence on the pathogenesis of homeostasis disorders at the organizational level and to form the evidence base of a new symptom complex - renal distress syndrome in surgery and uronephrology; to establish the effectiveness of Remaxol in its correction.

Material And Methods: Experimentally on 60 mongrel dogs with acute peritonitis, pancreatitis, intestinal obstruction of varying severity, the state of renal function, including detoxification, was assessed based on the assessment of the inflow-outflow difference in the level of toxins and in the parenchyma of organs - the composition of lipids, the activity of peroxidation of membrane lipids and phospholipases. Clinical and laboratory studies included patients with acute peritonitis (48), acute pancreatitis (18), intestinal obstruction (21), acute purulent secondary pyelonephritis (19).

[Problems and prospects of kinesiotaping use in clinical practice].

Currently the concept of kinesiotaping has become widespread. Kinesiotaping, which was originally implemented in sports medicine, is increasingly used in rehabilitation and various spheres of medicine, such as orthopedics, traumatology, pediatrics, etc. In recent years, the new publications about the kinesiotaping use in neurology and rheumatology have been released, where previously unknown effects, such as improved sensory feedback, have been demonstrated.

[Enteral protection in patients with diffuse peritonitis].

Objective: To improve treatment outcomes in patients with diffuse peritonitis via enteral protection using intestinal lavage with ozonized solution through an original tube.

Material And Methods: We analyzed 78 patients with advanced peritonitis. The control group included 39 patients who underwent standard measures after surgery for peritonitis.

[Possible ways to approach the effectiveness of open abdominal interventions to laparoscopic].

The Purpose Of The Work: Based on the determination of the mechanisms of negative manifestations of surgical aggression in open interventions, compared with laparoscopic, to determine ways to optimize the early postoperative period when using them.

Material And Methods: The work is based on clinical and laboratory analysis of 147 patients with acute appendicitis complicated by acute peritonitis. In the first group (=58), patients were operated with traditional laparotomy access.

[The variants of enteral distress syndrome correction with peritonitis].

Objective: To determine the effectiveness of a new treatment regimen for patients with widespread peritonitis with an accent on enteroprotection based on the use of a drug of the metabolic type of action of remaxol and physiotherapy.

Material And Methods: Clinical and laboratory studies of 82 patients with widespread peritonitis, mainly with grade 2 severity according to the Mannheim peritonitis Index, severe form - according to the ARASNE II scale. In the 1st group (28) patients underwent intraoperative intestinal intubation in the traditional way; in the 2nd (22) - intestinal intubation according to the original method; in the 3rd (32) - intestinal intubation according to the original method and combined use of remaxol (parenterally, enterally and intraperitoneally).

[Endotoxin production in the early stages of urgent abdominal pathology and correction ways].

Objective: To study the features of the development of endogenous intoxication in association with damage to the organs of the detoxification system, the severity of catabolic processes associated with the activity of peroxidation of membrane lipids and phospholipases in various urgent pathology of the abdomen, on the basis of which to develop a new pathogenetically based approach to the prevention of the progression of surgical endotoxicosis.

Material And Methods: . The studies were conducted in 162 patients with acute urgent pathology (seven groups) with predominant aseptic inflammation (acute severe pancreatitis, acute intestinal obstruction, acute catarrhal cholecystitis) and pronounced purulent-necrotic phenomena (acute peritonitis, acute destructive cholecystitis with empyema of the gallbladder).

Transcription Factors in Deriving β Cell Regeneration: A Potential Novel Therapeutic Target.

Recently, remarkable advances have been achieved in the molecular biopathology field and researchers turned to evaluate the role, molecular mechanisms, and clinical value of transcription factors in curing a variety of parenchymal degenerative pathologies. Special agents have the capability to cell lineage reprogramming termed transcription factors with a capacity for gene expression modification. Therefore, whatever niche factor may modify gene expression is termed as a transcription factor.

[Hepatic distress syndrome in surgery: concept, pathogenesis, prevention and correction].

Objective: To establish the universality and regularity of hepatic disorders, their role in pathogenesis of homeostasis impairment and determine scientific base for a new syndrome - hepatic distress syndrome in surgery.

Material And Methods: Chronic experiments on outbred dogs were carried out. Acute peritonitis was simulated in the first group (=15), acute destructive pancreatitis in the second group (=15), acute obstructive intestinal obstruction in the third group (15).

ASSESSMENT OF LASER AND ANTIOXIDANT THERAPY EFFICACY IN TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS.

Chronic generalized parodontitis is one of the most prevalent disorders among diseases of oral cavity, making the search for optimal treatment modalities of this disorder one of the mostressing matters to this day.  The purpose of this study was to assess outcomes of conventional therapy and secondary prevention of chronic generalized parodontitis with in combination with use of laser therapy and antioxidant drug treatment.   The study is presented as a joint multi-site investigation conducted by the group of authors from St.

[Systemic inflammatory response syndrome in pancreatic necrosis: triggers and organ damage].

Objective: To determine the main trigger mechanisms of multiple organ failure in acute severe pancreatitis.

Material And Methods: An experimental study included 26 dogs with pancreatic necrosis. We assessed homeostasis disorders and functional changes in the pancreas, bowel, liver, kidneys, lungs and heart.

[Systemic coagulopathic distress syndrome in surgery: concept, pathogenesis, prophylaxis].

Objective: The purpose of the study is to determine the correlation of changes in the humoral and tissue components of the hemostasis system with lipid metabolism in case of various urgent surgical diseases, on the basis of which the systemic coagulopathic distress syndrome can be used as the scientific basis for the definition of a new syndrome.

Material And Methods: The work includes the results of experimental and clinical laboratory tests. Experiments on dogs: in the first group (n=18) destructive pancreatitis; in the second (n=18) - fecal peritonitis; in the third (n=15), acute obstructive intestinal obstruction; in the fourth (n=16) fecal peritonitis, in the postoperative period, Remaxol (15 ml/kg) was included in the therapy.

[Intensification of the organism detoxification ability under surgical endogenous intoxication].

Unlabelled: The purpose of the study is to establish the effectiveness of remaxol in the correction of endogenous intoxication in patients with acute peritonitis.

Material And Methods: The work is based on the results of clinical and laboratory studies. The clinic examined 55 patients with acute moderate peritonitis as complication of various diseases (acute appendicitis, perforated gastric or duodenal ulcer, acute intestinal obstruction, acute destructive cholecystitis).

[Systemic membrane-destabilizing distress syndrome in surgery: concept, pathogenesis, diagnosis].

Aim: To justify the concept of systemic membrane-destabilizing distress syndrome in surgery via analysis of phospholipid bilayer of cell membranes of various organs in urgent surgical abdominal diseases.

Material And Methods: Experimental research on dogs (n=90) included modeling of peritonitis, pancreatitis, intestinal obstruction, obstructive jaundice, and post-hemorrhagic anemia. Clinical and laboratory studies were performed in patients (n=119) with acute peritonitis, severe pancreatitis, intestinal obstruction, post-hemorrhagic anemia, acute cholecystitis, gastrointestinal bleeding, benign mechanical jaundice.

[Restoration of tissue reparative ability during acute pancreatitis (in Russian only)].

Aim: The purpose of the study was to establish the effectiveness of Remaxol in restoring tissue reparative ability of laparotomy wound in acute severe pancreatitis.

Material And Methods: The work is based on the results of experimental and clinical studies. Experiments were carried out using acute total pancreatic necrosis model under anesthesia on 30 dogs.

[The condition of the hemostatic system in acute severe peritonitis during remaxol therapy].

Aim: To evaluate the effectiveness of the Remaxol in the correction of hemostatic system in patients with severe acute peritonitis.

Material And Methods: 52 patients with acute peritonitis of different severity were examined, and divided into 4 groups: I - mild, II - moderate, III - severe. The patients of these groups had treated using standard therapy.

[Possibilities of tissue repair induction during mechanical jaundice of non-tumor genesis].

Aim: The aim of this research was to study the effects of complex therapy with Remaxol inclusion on laparotomy wound tissue reparative process in patients with obstructive jaundice in early postoperative period.

Material And Methods: Clinical and laboratory studies were carried out in 55 patients undergoing surgery of the biliary tract, including 35 patients with mechanical jaundice of non-tumor origin and 17 of them received Remaxol (for 5 days daily intravenous infusions of 400 ml each) in the early postoperative period.

Results: It has been proved that mechanical jaundice is a significant complication in the reparative process of laparotomy wound tissue structures.

Comparative Characteristics of the Methods of Treatment of Chronic Periodontitis Using Antibacterial Photodynamic Therapy (Per One Visit) and Calasept Preparation.

Background: The article describes the results of research on efficiency of using antimicrobial photodynamic therapy in treatment of chronic periodontitis.

Methods: 88 root canals in 84 patients were examined and treated. The diagnosis of chronic apical periodontitis was made based on anamnesis, data of clinical and instrumental examination, assessment of X-ray images.

[Increase of reparative potential of fabrics in sugar diabetes].

Aim: The purpose of the study was to study the effectiveness of the domestic drug Remaxol in reparative processes of laparotomic wound tissues in acute surgical abdominal pathology in patients with diabetes mellitus.

Material And Methods: Clinical and laboratory studies were performed in 86 patients with acute surgical pathology of the abdominal cavity, 56 patients with type 1 diabetes mellitus, including 26 patients who received Remaxol in the early postoperative period (daily intravenous infusions of 400.0 ml for 5 days).

Metabolic Restructuring in the Liver under Conditions of Endogenous Intoxication.

Significant metabolic alterations in the liver were observed in dogs with modeled acute peritonitis. These changes significantly impaired detoxification function of the liver, which was seen from the increase in the titer of toxic products in the early post-surgery period not only in the lymph, but also in the blood plasma. The key pathogenic mechanism leading to acute liver failure is destabilization of cell membrane resulting from LPO, phospholipase activity, and tissue hypoxia.

[Optimization of tissue reparation at treatment by Remaxol].

Aim: Studying influence of remaxol on reparative process of tissue reparation in a laparotomy wound.

Material And Methods: 90 patients with the acute appendicitis complicated by local peritonitis in the early postoperative period are examined. 50 patients received traditional therapy.

[Effect of the auxin polar transport inhibitor on the morphogenesis of leaves and generative structures during fasciation in Arabidopsis thaliana (L.) Heynh].

An increase in the proliferative activity of a shoot apical meristem (SAM) and the further accumulation of a pool of undifferentiated cells (fasciation) results in phyllotaxis changes. In the case of Arabidopsis thaliana, a typical spiral leaf arrangement is replaced by an opposite or verticillate one (depending on the level of a fasciation manifestation). Pistil development in mutant plants is accompanied by the appearance of a group of undifferentiated meristematic cells in its central part.

[Hemoglobin oxygen transport capacity in surgical endotoxicosis ].

In surgical endointoxication hemoglobin oxygen transport capacity of red blood cells (hemoglobin affinity ligands: the ability to bind and release ligands) is reduced and is associated with the severity of endogenous intoxication. Violation of oxygen transport function of hemoglobin at endogenous intoxication is associated with conformational changes of a biomolecule, and its possible influence on reactive oxygen species, which confirmed in experiments in vitro: under the influence of oxygen-iron ascorbate ability of hemoglobin deteriorates. Largely similar structural and functional changes in hemoglobin occur in patients with surgical endotoxicosis.