Publications by authors named "Vlahos N"

Purpose: to compare the Anti-Müllerian hormone (AMH) plasma concentrations of pre-pubertal and pubertal daughters born to polycystic ovary syndrome (PCOS) mothers to daughters born to control mothers and to investigate their alterations during pre-puberty and all stages of puberty.

Methods: We critically investigated and meta-analyzed observational studies, which compared the plasma concentrations of AMH in pre-pubertal and pubertal daughters of PCOS pregnancies. A search of the literature was completed till the end of June of 2024 in the PubMed, Scopus, and Medline for the eligible studies.

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PAG aims to foster a collaborative environment that bridges knowledge from various disciplines to ensure the highest quality of care for children and adolescents with gynaecological issues. The European Association of PAG and HellenicPAG, like all National PAG Societies, support research and education to advance new insights, improve health outcomes, enhance quality of life, and protect future fertility. Additionally, PAG promotes international cooperation by proposing guidelines for good clinical practice in terms of prevention, diagnosis, procedures, and treatment.

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This is the case of a 30-year-old nulliparous patient with a complete uterine septum, double cervix and non- obstructive longitudinal vaginal septum (Class U2bC2V1 according to the ESHRE/ESGE classification). The patient presented with severe dyspareunia and dysmenorrhea. Imaging revealed a complex Müllerian anomaly and hysteroscopic treatment was agreed.

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Article Synopsis
  • The rise of uterine isthmocele, tied to increasing cesarean section rates, affects about 60% of women with cesarean histories, leading to its classification as cesarean scar disorder (CSD).
  • Diagnosis is achievable through various imaging techniques, and management may involve either pharmacological or surgical options.
  • Surgical treatments, such as hysteroscopic resection, laparoscopic, and vaginal methods, vary in effectiveness and complications, with hysteroscopic treatment being the safest, although decisions should be tailored to individual patient factors, particularly residual myometrial thickness (RMT).
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Gynecological cancer is a term referring to malignancies that typically involve ovarian, cervical, uterine, vaginal, and vulvar cancer. Combined, these cancers represent major causes of morbidity and mortality in women with a heavy socioeconomic impact. MiRNAs are small non-coding RNAs that are intensively studied in the field of cancer and changes in them have been linked to a variety of processes involved in cancer that range from tumorigenesis to prognosis and metastatic potential.

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Endocrine-disrupting chemicals (EDCs) are environmental and industrial agents that interfere with hormonal functions. EDC exposure is linked to various endocrine diseases, especially in reproduction, although the mechanisms remain unclear and effects vary among individuals. Neuroinflammation, particularly hypothalamic inflammation, is an emerging research area with implications for endocrine-related diseases like obesity.

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  • Endometrial cancer (EC) is on the rise and linked to factors like unopposed estrogen, insulin resistance, and chronic inflammation, particularly in the context of obesity and type 2 diabetes.
  • Recent studies suggest that drugs like metformin, used for diabetes management, may help prevent EC, highlighting the role of insulin resistance in its development.
  • The study aims to investigate the potential of glucagon-like peptide-1 (GLP-1) receptor agonists (RAs), which have various functions and may induce apoptosis in cancer cells, for non-surgical treatment of endometrial cancer, although more research is needed to fully understand their role in this context.
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To assess the effect of hysteroscopic polypectomy on the in vitro fertilization (IVF) results in infertile women with at least one prior negative IVF outcome. This retrospective cohort study included women who had attended the "2nd Department of Obstetrics and Gynecology of the National and Kapodistrian University of Athens" and "Iaso" Maternity Hospital from October 2019 to January 2023 for infertility treatment. The medical records of 345 women aged 18-45 years old without abnormal findings in hysterosalpingography (HSG) and with at least one previous failed IVF procedure were analyzed.

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  • The study examined how starvation and refeeding impact the growth and food intake of gilthead seabream and seabass, as well as the growth of glasswort, in a 75-day aquaponic system with a salt concentration of 12 ppt.
  • Nine aquaponic setups were tested with varying feeding schedules: a control group fed daily, a 4-day fasting group, and a 7-day fasting group.
  • Results indicated that while 4 days of fasting allowed fish to achieve near control growth levels, the 7-day fasting significantly hindered growth; however, it positively influenced the growth of glasswort compared to the control.
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  • The study aims to investigate the rising cesarean section rates in Greece and implement interventions to promote vaginal delivery through a trial named ENGAGE, focusing on evidence-based practices.
  • Twenty-two maternity units across Greece will participate in a multicenter trial involving 20,000 to 25,000 births, employing a stepped-wedge design whereby units will gradually implement interventions over 8-18 months.
  • Key interventions include applying updated clinical guidelines, training on cardiotocography, and providing ongoing support to healthcare professionals, with data on cesarean rates and outcomes collected for analysis throughout the study.
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Introduction: Over the past decade, digital education has seen widespread adoption, particularly accentuated during the COVID-19 pandemic. The post-COVID era has further emphasized the advantages of digital education in terms of cost, availability, and sustainability. However, concerns regarding the efficacy of digital education, particularly in skills-based learning and the absence of social interaction, have been raised.

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The onset of puberty, which is under the control of the hypothalamic-pituitary-gonadal (HPG) axis, is influenced by various factors, including obesity, which has been associated with the earlier onset of puberty. Obesity-induced hypothalamic inflammation may cause premature activation of gonadotropin-releasing hormone (GnRH) neurons, resulting in the development of precocious or early puberty. Mechanisms involving phoenixin action and hypothalamic microglial cells are implicated.

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Background: Reproduction ability requires a certain amount of body fat that is necessary for ovulation, menstruation and pregnancy. Fat tissue represents an endocrine organ with high metabolic activity as it produces adipokines such as leptin and adiponectin. Our aim is to examine potential associations between women of reproductive age's ovarian reserves and their levels of leptin and adiponectin.

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Background: The capabilities of minimally invasive surgery, either as conventional laparoscopy, or as robotic surgery, have increased to an extent that it enables complex operations in the field of gynaecological oncology.

Objective: To document the role of minimally invasive gynaecological surgery in cancer.

Materials And Methods: A review of the literature that shaped international guidelines and clinical practice.

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Objective: The genitourinary syndrome of menopause (GSM) is often underdiagnosed and undertreated despite its significant impact on postmenopausal quality of life. We assessed the prevalence of GSM and associated symptoms in Greek perimenopausal/postmenopausal women attending gynecology clinics.

Methods: Four hundred and fifty women, aged 40-70 years (93.

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Infertility is a modern health problem. Obesity is another expanding health issue associated with chronic diseases among which infertility is also included. This review will focus on the effects of weight loss by medical therapy on fertility regarding reproductive hormonal profile, ovulation rates, time to pregnancy, implantation rates, pregnancy rates, normal embryo development, and live birth rates.

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Background: Since its introduction, assisted reproductive technology (ART) has developed into a common clinical practice around the world; yet it still raises a lot of questions. Throughout time, many researchers have investigated its association with several obstetric incidences and its consequences on perinatal outcomes. The aim of the current meta-analysis was to estimate the correlation between ART procedures and malpresentation of the fetus in singleton pregnancies.

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Article Synopsis
  • The genitourinary syndrome of menopause (GSM) includes vulvovaginal atrophy (VVA) and lower urinary tract symptoms (LUTS), which are prevalent in menopausal women due to shared developmental origins and estrogen receptor presence.
  • A study of 450 Greek peri- and postmenopausal women revealed that over half experienced urinary urgency or frequency, with varying degrees of severity in symptoms like dysuria.
  • Findings show a correlation between LUTS and VVA symptoms, highlighting the need for early assessment of these issues to improve the quality of life for women undergoing menopause.*
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Introduction: Endometriosis, defined as the presence of endometrial glands and stroma outside the uterine cavity, mainly affects the pelvic viscera and peritoneum. Endometriosis can also occur at sites of surgical incisions on the abdominal wall, mainly in women with a history of cesarean section (CS). The incidence of abdominal wall endometriosis after CS reaches 1%.

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  • * Factors influencing the success of egg freezing include the woman's age, the number of eggs retrieved, and individual health conditions, but potential risks exist for both the mother and embryo during the in vitro fertilization process.
  • * There is a growing interest in egg freezing, particularly in countries like the USA and Israel, but issues like high costs, lack of official data in some regions like Greece, and varying legal structures highlight the need for more research and a universal legal framework to support women's reproductive choices.
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The aim of this systematic review was to examine if chronic or acute stress, measured by questionnaires or physiological biomarkers, has a separate impact on each different stage in the IVF process. A systematic search of peer-reviewed literature was performed in three databases with keywords. Preselection included 46 articles, and in all, 36 articles were included.

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  • Chronic stress during pregnancy can negatively impact both mothers and infants, leading to health risks and hormonal disruptions.
  • A meta-analysis of 107 studies found a significant association between maternal chronic stress and low birth weight babies, with a notable risk factor identified (OR = 1.50).
  • The study suggests that using stress questionnaires for mothers could help predict and assess the risk of having a low-birth-weight infant.
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Purpose: There is currently a heightened need for perinatal medical services to timely recognize and accurately meet the psychological needs of pregnant women. Psychological disturbances a mother experiences during pregnancy, such as depression and anxiety, can be later associated with inadequate maternal capacity for antenatal care for herself and the baby, and may lead to subsequent mental health problems later in the mother's life. Routine prenatal assessment could significantly benefit from being proactively enriched with early prevention mental health screening tools to assess, appropriately manage vulnerable populations, and subsequently implement preventive actions.

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Background: Female sexual dysfunction (FSD) has been suggested to be correlated with the burden of cardiovascular risk factors.

Aim: We aimed to evaluate the possible association between functional indices of vascular function and FSD scores in apparently healthy postmenopausal women.

Methods: This cross-sectional study included 116 postmenopausal women who underwent assessment of endothelial function with measurement of flow-mediated dilation (FMD) of the branchial artery and arterial stiffness estimation with measurement of the carotid-femoral pulse wave velocity (PWV).

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Introduction: Thrombophilic genetic polymorphisms of the platelet glycoproteins Ia (GpIa) and IIIa (GpIIIa) have been associated with an increased risk of recurrent miscarriages. The aim of this study was to investigate the association of genetic polymorphisms GpIa-C807T and GpIIIa-T1565C-PlA1/PlA2 with platelet function in women with unexplained spontaneous recurrent miscarriages.

Methods: This cross-sectional study comprised 196 unrelated nulliparous Greek women with a history of unexplained recurrent miscarriages.

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