Publications by authors named "Vlaho M"

A combination of amoxicillin with clavulanic acid (a beta-lactamase inhibitor) and the aminoglycoside amikacin proved effective in the treatment of advanced pulmonary nocardiosis in a 49-year-old man. The result accorded with preceding in-vitro and animal experiments and justifies this combination of drugs in the treatment of nocardiosis, especially if the causative organism is N. farcinica (N.

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Two women had four supervised pregnancies after renal transplantation. A striking feature was that the children had fetal growth retardation which led to premature termination of pregnancy by section. Likely causes of the growth retardation are, in the first instance, long-term treatment with corticosteroids and increased incidence of toxaemia.

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A retrospective study of 332 dialysis patients (observation period up to 17 years) demonstrated that cardiovascular and cerebrovascular death rates due to atherosclerosis did not increase with length of time on dialysis. Data analysis showed that cardiovascular and cerebrovascular morbidity and mortality during dialysis is primarily caused by high blood pressure existing prior to commencement of dialysis and an unfavourable very low-density lipoprotein/high-density lipoprotein (VLDL/HDL) cholesterol quotient at the beginning of dialysis treatment. The treatment of the patient before acceptance onto dialysis seems therefore to be the determining factor in the prognosis on dialysis.

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Changes due to ageing appear increasingly during the last third of the lifespan, and the overall performance capability of the organism gradually declines. Loss of function of the kidney, a vital organ, in the form of acute renal failure represents a special hazard to older patients despite modern therapies including the use of the various forms of artificial kidney. In diagnosis, care must be taken to differentiate between functional renal insufficiency and genuine acute renal failure.

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We investigated active and inactive (acid-activatable) plasma renin in anephric and in normal persons. In anephric patients (n = 15) plasma concentration of active and inactive renin was 1.15 +/-- 0.

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In 60 patients of our dialysis program lowered zinc levels as well as increased chromium levels were observed in serum. These alterations were compared to the parameters of glucose and lipid metabolism. Furthermore, a negative correlation of chromium and HDL-cholesterol levels could be observed.

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It was found experimentally that the activity of the urea-cycle enzymes in the leucocytes of uraemic rats was parallel to that in their liver. Conclusions as to the activity of the urea-cycle enzymes in the liver can thus be drawn from the urea-cycle enzyme activity in the leucocytes. Investigation of the urea-cycle enzyme in the leucocytes of patients with renal insufficiency, in the pre-dialytic and dialytic states, showed that in both groups the ornithine carbamoyl transferase and the argininosuccinate lyase activity was lower in both groups of patients than in normal persons.

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Active renin was detected in 6 of 7 anephric patients (mean value: 0.72 +/- 0.27 microU/ml, n = 7; normals: 19.

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