Metabolic remodelling of mice by hypoxic-hypercapnic environment: imitating the naked mole-rat.

We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not require external sources of gases or complex technical equipment. Here, we showed for the first time that a chronic exposure of mice to HHE could be a unique tool for NMR-like metabolic remodeling, resulting in a long-term and substantial decrease in metabolic rate, body temperature, and food consumption, without significant changes in expression of stress-related genes.

Biogerontology in Ukraine: update.

Recent biogerontological findings in Ukraine are critically reviewed. It is stressed that cooperation of efforts within and between departments, institutions and countries is an efficient mode of coping with the complex problems of aging. A wide spectrum of aging research was traditionally performed in state-funded institutions throughout the country, focusing primarily on the neuro-humoral regulation, immune system, adaptation, oxidative stress, comparative analysis and life span extension.

Pair-wise linear and 3D nonlinear relationships between the liver antioxidant enzyme activities and the rate of body oxygen consumption in mice.

Relationships between the rate of body oxygen consumption (VO2) and the liver key antioxidant enzyme activities were assessed in female CBA mice. The pair-wise linear regression and correlation demonstrated significant correlative links between VO2 and activity of catalase (CAT). Nonlinear 3D plotting revealed a complementary pattern of CAT and glutathione peroxidase (GP) relation.