Publications by authors named "Vladislav Ryvkin"
Article Synopsis
- PKD is a family of three kinases (PKD-1, -2, and -3) that regulate key biological processes like cell growth, migration, and survival; PKD1 is especially crucial for wound healing and tumor development in mice.
- Unlike in mice, PKD1 is absent in human skin cells (keratinocytes), leading to differences in how PKD isoforms function in humans, particularly regarding cell growth responses.
- The study shows that PKD2 promotes growth in human keratinocytes, while PKD3 is essential for cell proliferation; loss of PKD3 leads to severe proliferation issues and an inability to properly regenerate tissue, highlighting the complexity of PKD signaling in skin health.
