Publications by authors named "Vladislav Biriukov"
Candida auris is a growing concern due to its resistance to antifungal drugs, particularly amphotericin B (AMB), detected in 30 to 60% of clinical isolates. However, the mechanisms of AMB resistance remain poorly understood. Here we investigated 441 in vitro- and in vivo-evolved C.
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- Antifungal drug resistance is a significant global health issue, prompting the need for new treatment strategies that involve understanding collateral sensitivity and cross-resistance in pathogenic fungi.
- A study on Candida auris revealed that using collateral sensitivity-based drug cycling can effectively prevent drug resistance from developing and can help eliminate resistant sub-populations.
- The findings indicate that incorporating collateral sensitivity into treatment decisions could lead to better antifungal therapies, as certain sensitivity trends appear consistent across different strains and resistance mechanisms.
Bioluminescent solid-phase analysis was proposed to monitor the selection process and to determine binding characteristics of the aptamer-target complexes during design and development of the specific aptamers. The assay involves Ca -regulated photoprotein obelin as a simple, sensitive and fast reporter. Applicability and the prospects of the approach were exemplified by identification of DNA aptamers to cardiac troponin I, a highly specific early biomarker for acute myocardial infarction.
View Article and Find Full Text PDFBackground: Species in the genus Armillaria (fungi, basidiomycota) are well-known as saprophytes and pathogens on plants. Many of them cause white-rot root disease in diverse woody plants worldwide. Mitochondrial genomes (mitogenomes) are widely used in evolutionary and population studies, but despite the importance and wide distribution of Armillaria, the complete mitogenomes have not previously been reported for this genus.
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