Publications by authors named "Vladimirova N"

Unlabelled: Diaphragm dysfunction develops in central nervous system damage, chest injuries, complications of cardiac surgery, long-term artificial lung ventilation, respiratory diseases. Anatomical morphological features of phrenic nerves allow to effectively use electromagnetic stimulation methods for functional recovery of the diaphragm in different pathological conditions. Invasive and non-invasive, electric and magnetic methods of stimulation are used depending on the severity of manifestations of the diaphragm dysfunction and its genesis.

View Article and Find Full Text PDF

Introduction: In patients with inflammatory bowel disease (IBD), co-occurring spondyloarthritis (SpA) leads to poorer outcomes and impaired quality of life, highlighting the importance of early detection and effective treatment. This is the first study to assess the prevalence and distribution of axial symptoms and magnetic resonance imaging (MRI)-detected involvement of the spine and sacroiliac joints (SIJs) in early IBD.

Methods: Newly diagnosed patients with IBD from a prospective, population-based cohort were consecutively recruited.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to compare the effectiveness of MRI-based synthetic CT (sCT), low-dose CT (ldCT), and radiography in detecting new bone formation in patients with axial spondyloarthritis (axSpA).
  • Results showed that ldCT had the highest mean scores for detecting new bone lesions, while sCT performed significantly better than radiography, indicating its potential as a valuable imaging tool.
  • The conclusion emphasized that sCT exhibited high specificity and improved sensitivity compared to radiography, suggesting it could be crucial for monitoring spine damage in axSpA, especially in clinical research settings.
View Article and Find Full Text PDF

Objectives: Musculoskeletal [MSK] manifestations in patients with inflammatory bowel disease [IBD] are common and associated with poorer outcomes. Hence, early detection is important to optimally tailor treatment. We aimed to determine the prevalence and distribution of inflammatory lesions in peripheral joints and entheses in newly diagnosed IBD patients.

View Article and Find Full Text PDF

Background: The Spondyloarthritis Research Consortium of Canada (SPARCC) developers have created web-based calibration modules for the SPARCC MRI sacroiliac joint (SIJ) scoring methods. We aimed to test the impact of applying these e-modules on the feasibility and reliability of these methods.

Methods: The SPARCC-SIJ e-modules contain cases with baseline and follow-up scans and an online scoring interface.

View Article and Find Full Text PDF
Article Synopsis
  • The study analyzes the impact of the COVID-19 pandemic on the epidemiology of respiratory syncytial virus (RSV) in Europe from October 2020 to September 2022.
  • Data from multiple surveillance systems showed a significant drop in RSV detections during the 2020/21 season, followed by a gradual increase in 2021 and notable peaks in 2021/22.
  • Despite increased testing, RSV patterns were disrupted, with unusual circulation trends observed, indicating that normalization of RSV activity had not been achieved by the 2022/23 season.
View Article and Find Full Text PDF

In a context of recently decreasing childhood immunization coverage and low uptake of COVID-19 vaccines in Bulgaria, this study measures vaccine hesitancy among general practitioners (GPs) in the country, as they are central to forming patients' attitudes. In 2022, a face-to-face survey was conducted through a simple random sample from an exhaustive national database of Bulgarian GPs. This study measured attitudes on vaccine importance, safety, and effectiveness, and attitudes toward the Bulgarian immunization schedule.

View Article and Find Full Text PDF

The communication practices of general practitioners in relation with vaccines have not been a topic of wide scientific interest. In this article, we outline them in the context of Bulgaria. A representative, cross-sectional, quantitative, face-to-face survey was conducted among 358 Bulgarian general practitioners in 2022 using simple random sampling.

View Article and Find Full Text PDF

We suggest a new focus for turbulence studies-multimode correlations-which reveal the hitherto hidden nature of turbulent state. We apply this approach to shell models describing basic properties of turbulence. The family of such models allows one to study turbulence close to thermal equilibrium, which happens when the interaction time weakly depends on the mode number.

View Article and Find Full Text PDF

While potentiometric, plasticized membrane sensors are known as convenient, portable and inexpensive analytical instruments, their development is time- and resource-consuming, with a poorly predictable outcome. In this study, we investigated the applicability of the QSPR (quantitative structure-property relationship) method for predicting the potentiometric sensitivity of plasticized polymeric membrane sensors, using the ionophore chemical structure as model input. The QSPR model was based on the literature data on sensitivity, from previously studied, structurally similar ionophores, and it has shown reasonably good metrics in relating ionophore structures to their sensitivities towards Cu, Cd and Pb.

View Article and Find Full Text PDF

The treatment of agricultural crops with entomopathogenic fungi may disturb the structure of soil microarthropod communities, which can have an adverse impact on soil fertility and, ultimately, on the yield. The effect of the treatment of broad bean ( L.) seeds, with the entomopathogenic fungus , on the abundance and community structure of soil microarthropods in the rhizosphere was assessed in different phases of plant vegetation in a two-year experiment.

View Article and Find Full Text PDF
Article Synopsis
  • Inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis are chronic conditions affecting the gastrointestinal tract, and a study has been launched in Denmark to explore their varied progression and treatment responses.
  • The IBD Prognosis Study is a comprehensive, population-based research involving newly diagnosed IBD patients of all ages from a region covering around 1.05 million people, following strict diagnostic criteria for accurate identification.
  • The study’s methods include regular clinical assessments, various imaging techniques, and systematic sample collection to analyze biomarkers, microbiome, and genetic information, alongside evaluating the impact of environmental factors and extraintestinal complications.
View Article and Find Full Text PDF

This note is devoted to broken and emerging scale invariance of turbulence. Pumping breaks the symmetry: the statistics of every mode explicitly depend on the distance from the pumping. And yet the ratios of mode amplitudes, called Kolmogorov multipliers, are known to approach scale-invariant statistics away from the pumping.

View Article and Find Full Text PDF

When two resonantly interacting modes are in contact with a thermostat, their statistics is exactly Gaussian and the modes are statistically independent despite strong interaction. Considering a noise-driven system, we show that when one mode is pumped and another dissipates, the statistics of such cascades is never close to Gaussian, no matter what is the relation between interaction and noise. One finds substantial phase correlation in the limit of strong interaction or weak noise.

View Article and Find Full Text PDF

Background: Limited data exist regarding the disease course of coronavirus disease 2019 (COVID-19) and its relationship with immunosuppressants among patients with immune-mediated inflammatory diseases (IMIDs). Therefore, this study aims to investigate the association between COVID-19, frequent rheumatological, dermatological, gastrointestinal, and neurological IMIDs and immunosuppressants.

Methods: We conducted a Danish population-based cohort study including all residents living within Capital Region of Denmark and Region Zealand from January 28th, 2020 until September 15th, 2020 with the only eligibility criterion being a test for SARS-CoV-2 via reverse transcription-polymerase chain-reaction.

View Article and Find Full Text PDF

In this work, a chemical reaction between gaseous ozone and aqueous solution of Mn(CHCOO) in drops has been researched. It has been shown that the formation of H MnO·nHO nanocrystals with a morphology of nanosheets and a birnessite-like crystal structure with a thickness of 5-8 nm is observed on the surface of drops. These nanocrystals are oriented spontaneously to the solution-gas interface and constitute peculiar ribbons with a width of 1-2 μm, some of which form ordered honeycomb structures (OHS) with a 5-20 μm cell size.

View Article and Find Full Text PDF

Forest biomass is an essential indicator for monitoring the Earth's ecosystems and climate. It is a critical input to greenhouse gas accounting, estimation of carbon losses and forest degradation, assessment of renewable energy potential, and for developing climate change mitigation policies such as REDD+, among others. Wall-to-wall mapping of aboveground biomass (AGB) is now possible with satellite remote sensing (RS).

View Article and Find Full Text PDF

BackgroundQ fever is a zoonosis, included in category B of particularly dangerous infectious agents and as such merits careful surveillance and regular updating of the information about its distribution.AimThis observational retrospective study aimed to provide an overview of Q fever incidence in Bulgaria in the period 2011 to 2017.MethodsAggregated surveillance data from Bulgaria's mandatory surveillance system, laboratory data on individual samples received at the National Reference Laboratory Rickettsiae and Cell Cultures and outbreak reports sent by the regional health authorities to the National Centre of Infectious and Parasitic Diseases, were used in this analysis.

View Article and Find Full Text PDF

Background: Meningococcal disease continues to be a global public health concern due to its epidemic potential, severity, and sequelae. The global epidemiological data on circulating meningococcal serogroups have never been reviewed concurrently with the laboratory capacity for meningococcal surveillance at the national level. We, therefore, aimed to conduct a country-level review of meningococcal surveillance, serogroup distribution, and vaccine use.

View Article and Find Full Text PDF

Flows in fluid layers are ubiquitous in industry, geophysics, and astrophysics. Large-scale flows in thin layers can be considered two dimensional with bottom friction added. Here we find that the properties of such flows depend dramatically on the way they are driven.

View Article and Find Full Text PDF

Here we study how coherence appears in a system driven by noise at small scales. In the wave turbulence modeled by the Gross-Pitaevskii or the nonlinear Schrödinger equation, we observe states with correlation scales smaller than the system size but much larger than the excitation scale. We call a such state precondensate to distinguish it from condensate defined as a systemwide coherent state.

View Article and Find Full Text PDF

From March to August 2017, 165 measles cases were reported from three regions in Bulgaria. The age range was 0-55 years and 66% of the cases were under 9 years. The Roma population was disproportionally affected (89% of cases), 41% cases were unvaccinated and in 24 cases there was nosocomial transmission mostly in paediatric departments.

View Article and Find Full Text PDF

We model combining of multiple laser beams into a single near diffraction-limited beam by beam self-focusing (collapse) in a Kerr medium. The beams with the total power above critical are combined in the near field and then propagated in the Kerr medium. Nonlinearity results in self-focusing event, combining multiple beams into nearly a diffraction-limited beam that carries the critical power.

View Article and Find Full Text PDF

Objectives. In some rheumatoid arthritis (RA) patients, joint pain persists without signs of inflammation. This indicates that central pain sensitisation may play a role in the generation of chronic pain in a subgroup of RA.

View Article and Find Full Text PDF
Cascades in nonlocal turbulence.

Phys Rev E Stat Nonlin Soft Matter Phys

April 2015

We consider developed turbulence in the two-dimensional Gross-Pitaevskii model, which describes wide classes of phenomena from atomic and optical physics to condensed matter, fluids, and plasma. The well-known difficulty of the problem is that the hypothetical local spectra of both inverse and direct cascades in the weak-turbulence approximation carry fluxes that are either zero or have the wrong sign; Such spectra cannot be realized. We analytically derive the exact flux constancy laws (analogs of Kolmogorov's 4/5 law for incompressible fluid turbulence), expressed via the fourth-order moment and valid for any nonlinearity.

View Article and Find Full Text PDF