ACE: the Advanced Cohort Engine for searching longitudinal patient records.

Objective: To propose a paradigm for a scalable time-aware clinical data search, and to describe the design, implementation and use of a search engine realizing this paradigm.

Materials And Methods: The Advanced Cohort Engine (ACE) uses a temporal query language and in-memory datastore of patient objects to provide a fast, scalable, and expressive time-aware search. ACE accepts data in the Observational Medicine Outcomes Partnership Common Data Model, and is configurable to balance performance with compute cost.

Profiling off-label prescriptions in cancer treatment using social health networks.

Objectives: To investigate using patient posts in social media as a resource to profile off-label prescriptions of cancer drugs.

Methods: We analyzed patient posts from the Inspire health forums (www.inspire.