Active ribosomal genes, translational homeostasis and oxidative stress in the pathogenesis of schizophrenia and autism.

Background: Infantile autism and schizophrenia are severe multifactorial disorders with a pronounced genetic predisposition. Their pathogeneses are often associated with oxidative stress in the brain. Previously, we established that a cell's resistance to oxidative stress depended on the copy number of transcriptionally active genes for rRNA (ribosomal genes) in the cell's genome.

On theoretical principles of constitution typology.

Constitution typology is thought of as a classification that is based on a few fundamental properties of the organism. These properties steadily distinguish individuals and permit the prediction of manifold secondary (external) features of types. At the transition from one constitutional type to another, concordant changes of trait values are determined by the respective changes of general causal factors.