Publications by authors named "Vladimir P Novoselov"
Article Synopsis
- This study investigates the use of metabolomic methods in forensic science to improve the accuracy of post-mortem interval (PMI) estimations by comparing human serum, aqueous humor (AH), and vitreous humor (VH).
- It finds that metabolomic changes in ocular fluids (AH and VH) occur more gradually than in serum, with specific metabolites like hypoxanthine and choline showing strong time correlations.
- The research concludes that analyzing AH and VH is more effective for PMI estimation than serum, highlighting the potential of these metabolites as biomarkers.
Spatial distribution of 34 metabolites along the optical and equatorial axes of the human lens has been determined. For the majority of metabolites, the homogeneous distribution has been observed. That suggests that the rate of the metabolite transformation in the lens is low due to the general metabolic passivity of the lens fiber cells.
View Article and Find Full Text PDFQuantitative metabolomic profiles of normal and cataractous human lenses were obtained with the combined use of high-frequency nuclear magnetic resonance (NMR) and high-performance liquid chromatography with high-resolution mass-spectrometric detection (LC-MS) methods. The concentration of more than fifty metabolites in the lens cortex and nucleus has been determined. For the majority of metabolites, their concentrations in the lens cortex and nucleus are similar, which confirms low metabolic activity in the lens core.
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