Publications by authors named "Vladimir Olegovich Karpov"
Objective: S-Adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are indicators of global transmethylation and may play an important role as markers of severity of COVID-19.
Methods: The levels of plasma SAM and SAH were determined in patients admitted with COVID-19 ( = 56, mean age = 61). Lung injury was identified by computed tomography (CT) in accordance with the CT0-4 classification.
Article Synopsis
- Aminothiols, like glutathione (GSH) and cysteinylglycine (CG), might be important in understanding the severity of COVID-19, but their exact role hasn't been fully explored yet.
- A study of 59 COVID-19 patients found that lower total glutathione (tGSH) levels were linked to a higher risk of severe illness and more lung damage, while levels of reduced cysteinylglycine (rCG) were also associated with lung injury.
- The findings suggest that tGSH and rCG could serve as useful indicators for assessing COVID-19 severity, highlighting the need to potentially adjust glutathione levels as part of treatment.