Publications by authors named "Vladimir N Kramskiy"
Article Synopsis
- - The study investigates the risk of saphenous nerve injury in patients who underwent knee surgery with adductor canal block (ACB) as part of their pain management.
- - Among 28,196 surgeries performed, only 18 cases (0.06%) of saphenous nerve injury were reported, primarily linked to anterior cruciate ligament (ACL) reconstruction.
- - While ACB was identified as a potential cause for some injuries, most were attributed to other factors, with varying prognoses for recovery reported among affected patients.
To determine if recent observations of hypoglycemia in patients receiving high-dose methadone extended to an animal model, we explored the effects of methadone and other mu-opioids on blood glucose levels in mice. Methadone lowered blood glucose in a dose-dependent manner with 20 mg/kg yielding a nadir in average glucose levels to 55 ± 6 mg/dL from a baseline of 172 ± 7 mg/dL, an effect that was antagonized by naloxone and mu selective antagonists β-funaltrexamine and naloxonazine. The effect was stereoselective and limited to only the l-isomer, while the d-isomer was ineffective.
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