Obesity and kidney transplantation.

Purpose Of Review: Obesity has reached epidemic proportions in the United States. It is a risk factor for developing, among others, heart disease, stroke, type 2 diabetes, and chronic kidney disease (CKD), and thus a major public health concern and driver of healthcare costs. Although the prevalence of obesity in the CKD/end-stage kidney disease population is increasing, many obese patients are excluded from the benefit of kidney transplant based on their BMI alone.

Assay Development and Validation of an 8-SNP Multiplex Test to Predict Eye and Skin Coloration.

Identifying human remains is one of the many responsibilities of forensic scientists. An eye- and skin-color predictor translates genotypic information into phenotypic description. Eight single nucleotide polymorphisms (SNPs) are utilized for this predictor, five for eye, and six for skin coloration.

Improved eye- and skin-color prediction based on 8 SNPs.

Aim: To improve the 7-plex system to predict eye and skin color by increasing precision and detailed phenotypic descriptions.

Methods: Analysis of an eighth single nucleotide polymorphism (SNP), rs12896399 (SLC24A4), showed a statistically significant association with human eye color (P=0.007) but a rather poor strength of agreement (κ=0.