Publications by authors named "Vladimir Drozdov"
Breast cancer (BC) is the prevailing malignancy and major cause of cancer-related death in females. Doxorubicin is a part of BC neoadjuvant and adjuvant chemotherapy regimens. The administration of anthracycline derivates, such as doxorubicin, may cause several side effects, including hematological disfunction, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, and cardiotoxicity.
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- The study aimed to evaluate the effectiveness of mid-regional proadrenomedullin (MR-proADM) compared to standard lab tests in assessing COVID-19 patients.
- A total of 140 hospitalized patients were monitored, with MR-proADM levels measured on their first and third days in the hospital, alongside other routine tests and the National Early Warning Score (NEWS) to indicate disease severity.
- Significant differences were found in age, hospitalization duration, and MR-proADM levels between patients who recovered and those who did not, indicating that MR-proADM could play a crucial role in identifying high-risk patients.
Objectives: A comparative dissolution kinetics test (CDKT) and bioequivalence studies of generic proton pump inhibitors (PPIs) do not model pharmacological acid suppression (PAS) and pathological duodenogastric reflux (PDGR). This study aimed to model them in CDKT to assess drugs stability and potential pantoprazole-clarithromycin interactions.
Methods: In CDKT, PDGR (dissolution medium pH 7.
Background: The main goal of our study was to explore the wound-healing property of a novel cerium-containing N-acethyl-6-aminohexanoate acid compound and determine key molecular targets of the compound mode of action in diabetic animals.
Methods: Cerium N-acetyl-6-aminohexanoate (laboratory name LHT-8-17) as a 10 mg/mL aquatic spray was used as wound experimental topical therapy. LHT-8-17 toxicity was assessed in human skin epidermal cell culture using (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
This paper presents the study results of NiMo/B O -Al O (0-30% wt. of B O ) catalysts for vegetable oil hydrodeoxygenation before and after catalytic tests by different electron paramagnetic resonance (EPR) methodologies. For the initial catalysts, the concentration of Brønsted acidic sites (BAS) determined by probe EPR with perylene increases linearly with an increase in the modifier (B O ) content in the samples.
View Article and Find Full Text PDFThermal evolution of Mg-Al and Ni-Al layered double hydroxides: the structure of the dehydrated phase.
Acta Crystallogr A Found Adv
November 2016
Simulation of X-ray diffraction patterns on the basis of the models of one-dimensional disordered crystals was used to investigate the structure of the dehydrated phase produced by dehydration of Mg-Al and Ni-Al layered double hydroxides at a temperature of ∼473-498 K. It was found that the removal of water molecules transforms the initial structure, which is a mixture of 3R and 2H polytypes, into a structure that comprises preferentially fragments of 3R and 1H polytypes and has some turbostratic disorder.
View Article and Find Full Text PDFBackground: Nonsteroid anti-inflammatory drugs represent an important osteoarthritis (OA) therapy component, but also a leading cause of gastropathy: one of the most frequent and serious OA therapy complications. The aim of the present study was to study the influence of GI health in an OA population receiving either ginger or diclofenac.
Methods: Forty-three (43) patients with confirmed OA (knee and hip) were included in a randomized controlled study.