Diazepam withdrawal syndrome: its prolonged and changing nature.

The diazepam withdrawal syndrome was studied in 10 patients who had abused the drug for 3 to 14 years. In the previous 6 months their consumption of diazepam had ranged from 60 to 120 mg daily; none had used other drugs during this period. The withdrawal period lasted about 6 weeks.

Protective role of trace metals in lead intoxication.

Protective effect of copper (Cu), zinc (Zn) or cobalt (Co) against lead (Pb) toxicity in rats was investigated. Trace metal administration together with Pb decreased the hepatic and renal uptake of lead and reduced the Pb-induced inhibition of blood delta-aminolevulinic acid dehydratase (delta-ALAD) activity. The hepatic uptake of Zn or Co was also increased in animals administered Pb and Zn or Pb and Co, respectively.

A Clinico-Aetiological Study of Exfoliative Dermatitis.

Twenty-five cases of exfoliative dermatitis (21 males and 4 females) were selected at random for study. in addition to routine history and clinical examination, investigations like histopathology of skin and lymphnodes, peripheral blood smear for abnormal cells and bone narrow examinations were done. Etiologically, the cases could be classified into three categories namely exfoliation in pre-existing dermatoses, drug incluced exfoliation and idiopathic exfoliation.

Flow cytometric measurement of nuclear DNA content variations as a potential in vivo mutagenicity test.

Mutagen-induced variations of the cellular DNA content have been studied in mouse bone marrow cells in vivo using high resolution flow cytometric techniques. During the first days after a single injection of the chemical mutagen cyclophosphamide an increased coefficient of variation in the G1 peak of the flow histograms was observed. The magnitude and duration of this effect were dose-dependent.

Applicability of Ridley-Jopling scale in clinical practice.

27 cases (90%) out of 30 cases studied could be graded clinically exact points of the scale. Out of the rest of 3 cases (10%); 2 cases (6.6%) required in between points of the scale.

Dermatoglyphics in Vitiligo.

A Total of 80 cases, comprising of 40 controls and 40 vitiligo cases, were studied for, dermatoglyphic pattern and ridge count. In males with vitiligo increased incidence of radial loops of 2nd fingers and increased incidence of arches were observed while in females, increased incidence of ulnar loops on 3rd digit was observed in the present study. Difference in patterns in cases of vitiligo as compared to normal, was statistically insignificant.

Dermatoglyphics in Ichthyosis and Alopecia Areata.

A total of 80 cases comprising of 40 controls and twenty each of ichthyosis and alopecia areata were studied for dermatoglyphic patterns and ridge count. Statistically significant increased incidence of whorl pattern was observed in female cases of autosomal dominant and sex linked ichthyosis. Significant change in the distribution of patterns was found in female cases of alopecia areata.

Septic and aseptic olecranon bursitis in patients on maintenance hemodialysis.

Over a period of four years, seven of 110 maintenance hemodialysis patients developed olecranon bursitis. In all patients it appeared in the arm on which AV access was constructed but one patient also had bilateral bursitis. None of the patients gave a history of trauma or gout.

Dermatoglyphics in Psoriasis.

Forty cases of psoriasis and same number of controls were subjected to dermatoglyphic studies. Control cases did not show any arch pattern on 4th and 5th fingers. Increased incinerate of whorl pattern was observed in psoriatic females and incidence was decreased in psoriatic males.

Carpal tunnel syndrome in patients undergoing maintenance hemodialysis.

Five of 62 maintenance hemodialysis patients were found to have carpal tunnel syndrome, and another five had prolonged distal motor latencies. Contrary to previous reports, there was no relation between carpal tunnel syndrome and the site of vascular access. Synovial biopsy specimens from flexor tendons demonstrated edema without inflammation, suggesting that extracellular fluid volume excess in the presence of flexion and immobility during dialysis may be pathogenetically important.