Publications by authors named "Vivienne Mae Galinato"
Neural basis of adolescent THC-induced potentiation of opioid responses later in life.
Neuropsychopharmacology
December 2024
Article Synopsis
- Adolescent exposure to THC (tetrahydrocannabinol) alters how morphine affects behavior in adulthood, impacting anxiety and drug-related responses.
- * In particular, THC exposure reduced anxiety during morphine withdrawal but increased the craving for morphine, indicating complex interactions between these substances.
- * Finally, the study identified changes in brain connectivity, particularly between the frontal cortex and dopamine regions, suggesting a neurological basis for how early THC exposure influences future responses to morphine.
Use of one drug of abuse typically influences the behavioral response to other drugs, either administered at the same time or a subsequent time point. The nature of the drugs being used, as well as the timing and dosing, also influence how these drugs interact. Here, we tested the effects of adolescent THC exposure on the development of morphine-induced behavioral adaptations following repeated morphine exposure during adulthood.
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