Publications by authors named "Vivienne Lubbat"
Article Synopsis
- Pick's disease (PiD) is a type of tauopathy linked to frontotemporal lobar degeneration, manifesting in dementia syndromes like primary progressive aphasia (PPA) and behavioral variant frontotemporal dementia (bvFTD).
- The study examined brain distributions of Pick bodies in cases of bvFTD and PPA using brain tissue samples, specifically targeting areas such as the middle frontal gyrus and anterior temporal lobe for pathology.
- Findings showed that bvFTD had higher densities of Pick bodies in the frontal region, while PPA showed more in the temporal lobe, with both disorders exhibiting significant hippocampal pathology that did not align with neocortical findings.
Objective: Age-related dementia syndromes are often not related to a single pathophysiological process, leading to multiple neuropathologies found at autopsy. An amnestic dementia syndrome can be associated with Alzheimer's disease (AD) with comorbid transactive response DNA-binding protein 43 (TDP-43) pathology (AD/TDP). Here, we investigated neuronal integrity and pathological burden of TDP-43 and tau, along the well-charted trisynaptic hippocampal circuit (dentate gyrus [DG], CA3, and CA1) in participants with amnestic dementia due to AD/TDP, amnestic dementia due to AD alone, or non-amnestic dementia due to TDP-43 proteinopathy associated with frontotemporal lobar degeneration (FTLD-TDP).
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