Objective: Cementochronology is a method for assessing chronological age and identifying other life-history parameters (LHPs) from incremental lines of acellular extrinsic fibre cementum (AEFC) in most mammalian teeth. The aim of this study is to question the accuracy of this technique when used as a stand-alone age estimation method, and to examine how the number of observers may alter accuracy.
Design: This research is based on an extant clinical study conducted on 10 human teeth with the patients' anamnestic data.
Angew Chem Int Ed Engl
November 2015
Transcribing exogenous RNA in eukaryotic cells requires delivering DNA to their nuclei and changing their genome. Nuclear delivery is often inefficient, limiting the potential scope of gene therapy and synthetic biology. These challenges may be overcome by techniques that allow for extranucleate transcription within eukaryotic cells.
View Article and Find Full Text PDFIron availability is a key regulator of virulence factor elaboration in Cryptococcus neoformans, the causative agent of fungal meningoencephalitis in HIV/AIDS patients. In addition, iron is an essential nutrient for pathogen proliferation in mammalian hosts but little is known about the mechanisms of iron sensing and uptake in fungal pathogens that attack humans. In this study, we mutagenized C.
View Article and Find Full Text PDF