Basic Pharmacological Characterization of EV-34, a New HS-Releasing Ibuprofen Derivative.

Background: Cardioprotective effects of HS are being suggested by numerous studies. Furthermore, HS plays a role in relaxation of vascular smooth muscle, protects against oxidative stress, and modulates inflammation. Long-term high-dose use of NSAIDs, such as ibuprofen, have been associated with enhanced cardiovascular risk.