Publications by authors named "Vivien Thom"
Article Synopsis
- The study investigates how certain immune cells, specifically dendritic cells (DCs), contribute to tissue damage in stroke.
- Using a mouse model, researchers found that conventional type 2 DCs rapidly infiltrate the ischemic brain and produce IL-23, which then leads to the activation of γδ T cells and neutrophil infiltration.
- The results indicate that targeting this IL-23/IL-17 pathway could potentially reduce brain damage and improve recovery in stroke patients.
Article Synopsis
- Acute ischemic and traumatic injuries to the central nervous system can trigger harmful inflammatory responses that result in further tissue damage, particularly observed in stroke cases.
- Recent research highlights how modulating the immune system could offer neuroprotective benefits, with intravenous immunoglobulin (IVIg) showing promise in treating both strokes and other acute brain injuries.
- IVIg, derived from the plasma of multiple donors, is commonly used for autoimmune diseases, and emerging studies suggest it may also effectively target inflammation and support neuronal health during acute CNS injuries.
Subtypes of primary angiitis of the CNS identified by MRI patterns reflect the size of affected vessels.
J Neurol Neurosurg Psychiatry
September 2017
Objective: To describe patterns of diagnostic findings, and identify subgroups of primary angiitis of the central nervous system (PACNS).
Methods: We retrospectively analysed 31 patients with PACNS. Cases were selected by predetermined diagnostic criteria and stratified into biopsy-proven and imaging-based PACNS.
IL-17 production by CSF lymphocytes as a biomarker for cerebral vasculitis.
Neurol Neuroimmunol Neuroinflamm
April 2016
Objective: To explore the possibility of using interleukin-17 (IL-17) production by CD4+ T cells in the CSF as a potential biomarker for cerebral vasculitis in stroke patients.
Methods: In this consecutive case study, we performed prospective analysis of CSF and blood in patients admitted to a university medical center with symptoms of stroke and suspected cerebral vasculitis. Flow cytometry was performed for intracellular detection of inflammatory cytokines in peripheral blood lymphocytes and expanded T cells from CSF.
The devastating effect of ischemic stroke is attenuated in mice lacking conventional and unconventional T cells, suggesting that inflammation enhances tissue damage in cerebral ischemia. We explored the functional role of αβ and γδ T cells in a murine model of stroke and distinguished 2 different T cell-dependent proinflammatory pathways in ischemia-reperfusion injury. IFN-γ produced by CD4(+) T cells induced TNF-α production in macrophages, whereas IL-17A secreted by γδ T cells led to neutrophil recruitment.
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