Publications by authors named "Vivien Su"
J Clin Invest
November 2023
Article Synopsis
- The interaction between white adipose cells and beige adipocytes plays a crucial role in obesity and insulin resistance, requiring the nuclear receptor PPARγ for function.
- Exposure to cold or adrenergic signals increases thermogenic cell activity through pathways that work alongside PPARγ, but the precise mechanisms of how PPARγ affects white adipose tissue's thermogenic response are unclear.
- The study identifies the long noncoding RNA Lexis as a regulator that influences thermogenic processes in adipose tissue, with its inhibition or deletion showing potential to reduce obesity and improve insulin sensitivity by increasing energy expenditure.
