Publications by authors named "Vivien Marasigan"
Article Synopsis
- The study investigates the impact of high-dose vitamin D supplementation on melanoma relapse in patients who have had curatively resected cutaneous melanoma (CM).* -
- A total of 436 patients were randomly assigned to either a vitamin D treatment group, receiving 100,000 IU monthly, or a placebo group, with follow-up lasting up to 116 months.* -
- Results showed that while vitamin D supplementation significantly increased serum levels, it did not noticeably improve relapse-free survival or reduce melanoma-related deaths compared to the placebo group.*
Article Synopsis
- Decreased expression of vitamin D receptors (VDR) in melanoma and melanocytic naevi compared to normal skin is observed, revealing a potential link to melanoma characteristics.
- A study involving 407 melanoma patients analyzed how VDR expression correlated with vitamin D levels, demographic factors, VDR genetic variants, and tumor pathology.
- Findings showed higher cytoplasmic VDR expression in patients with greater sun exposure and different genetic variants, while lower nuclear VDR expression was associated with tumor characteristics like mitosis and perineural invasion.
Article Synopsis
- Hidradenitis suppurativa (HS) is a complex skin condition that's tough to treat, with adalimumab being the only approved therapy and only helping about 50% of patients.
- The study investigated differences in gene expression between affected (lesional) and unaffected (nonlesional) skin in HS patients before and after 12 weeks of adalimumab treatment, aiming to uncover potential biomarkers for treatment response.
- Findings suggest significant immune system involvement in HS, with certain genes indicating treatment response and disease severity, pointing towards the need for personalized treatment strategies targeting specific immune pathways.
Vitamin D status is influenced by well-known determinants, but factors associated with low 25-hydroxyvitamin D levels in the cutaneous melanoma population are not well defined. The aim of this study was to confirm the well-known determinants and to assess new determinants for 25-hydroxyvitamin D levels in a cutaneous melanoma population. In a prospectively included cohort of 387 patients with cutaneous melanoma the association of 25-hydroxyvitamin D levels with sex, age, body mass index, time of blood withdrawal, Fitzpatrick phototype, vitamin D supplementation, score for intensity of lifetime sun exposure, smoking, education level, hair and skin colour, eye colour, total number of benign naevi, freckles and parameters of chronic sun damage was investigated.
View Article and Find Full Text PDFBackground: Melanoma is the fifth most common invasive cancer in Ireland, and incidence is increasing. Metastatic melanoma has been associated with poor overall survival historically. New systemic anti-cancer treatment (SACT) options for advanced melanoma have emerged in the last decade, and outcomes are improving.
View Article and Find Full Text PDFBackground: To investigate the contribution of individual and population factors to Coronary Heart Disease (CHD) mortality rates in Ireland between 2000 and 2015.
Methods: The Irish IMPACT CHD model was utilized with CHD Deaths Prevented or Postponed (DPPs) as outcome.
Results: CHD mortality rates in Ireland in those aged 25-84 years fell by 56% (63% in women vs.
The rising incidence of cutaneous melanoma and its stable high mortality rates despite innovative cancer care, require better prediction of the clinical outcome. In a large cutaneous melanoma population we explored whether the known clinical risk factors for melanoma susceptibility (nevus phenotype, phototype, family and personal history of melanoma and sun damage) affect melanoma outcomes. A total of 1,530 melanoma patients were included.
View Article and Find Full Text PDFThe rising incidence of cutaneous melanoma (CM), an aggressive skin cancer, emphasizes the need for novel biomarkers to guide personalized care and better predict outcome. Genetic factors including germline risk variants are promising candidates for this aim. We explored the association between germline risk variants and melanoma outcome in a large genetically homogenous Belgian melanoma population, focusing on single nucleotide polymorphisms which generated the highest association with melanoma susceptibility.
View Article and Find Full Text PDFInverse Association Between Atopy and Melanoma: A Case-control Study.
Acta Derm Venereol
January 2017
Heightened cutaneous immune surveillance in atopic patients may inhibit development of melanoma. The aim of this study was to analyse the association between atopy and melanoma (development and outcome). A total of 188 cases of melanoma and 596 healthy controls were interviewed by telephone with a standardized questionnaire on atopic, demographic and melanoma characteristics.
View Article and Find Full Text PDF