Publications by authors named "Vivien A Dolby"

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI).

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Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets.

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Article Synopsis
  • * A study looked at 2,643 pregnant women and found that more caffeine during early pregnancy is linked to higher chances of losing the baby later.
  • * Women who had late miscarriages or stillbirths drank more caffeine (about 145 mg/day) than those who had healthy babies (about 103 mg/day).
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