Publications by authors named "Viviane de Sousa Magalhaes"
Background: Brazilian spotted fever (BSF), the most lethal tick-borne disease in the Western Hemisphere, is caused by the bacterium Rickettsia rickettsii and transmitted by the bite of Amblyomma sculptum. Capybaras are considered primary hosts of this tick and amplifier hosts of R. rickettsii, generating new infected lineages of A.
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- Fipronil (FIP) is a topical ectoparasiticide that shows promise for oral administration due to risks of human exposure and environmental damage from existing formulations.
- Evidence from studies demonstrated that FIP is effective against fleas and ticks in dogs, with optimal dosages providing near-complete efficacy at 48 hours post-treatment.
- The pharmacokinetics of FIP indicated rapid absorption and metabolism but slower elimination, suggesting its potential as a safer and effective oral treatment option that aligns with the One Health concept for better health outcomes for animals, humans, and the environment.
Increased human-pet interactions have led to concerns related to the prevention and treatment of ectoparasite infestations. Fipronil (FIP) is a widely used ectoparasiticide in veterinary medicine available for topical administration; however, its use may cause damage to the owners and the environment. The aim of the study was to develop immediate-release tablets of FIP, as well as to determine its pharmacokinetic properties after oral administration in beagle dogs.
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