Pregabalin alters reproductive performance in male mice and causes congenital anomalies in offspring.

Context: Pregabalin is an anticonvulsant drug with analgesic activity for the treatment of neuropathic pain.

Aims: To valuate the toxicity of pregabalin in reproductive parameters, spermatogenesis, and teratogenicity in the offspring of mice.

Methods: Twenty male mice were randomly distributed into two groups: PGB group and group C (n =10 per group).