Publications by authors named "Viviane Smayra"
Article Synopsis
- The study investigates the role of TRPC3, a non-selective cation channel, in regulating insulin secretion and glucose control through glucose-stimulated calcium pathways.
- Experimental methods included using pharmacological tools and Trpc3 mice to evaluate TRPC3's effect on insulin secretion in both human and animal islets, as well as its involvement in glucose uptake and calcium imaging.
- The findings suggest that TRPC3 is crucial for insulin secretion but not for glucose uptake, and its modulation may offer new therapeutic strategies for treating diabetes.
Idiopathic inflammatory myositis (IIM) is a group of rare diseases of unknown etiology, with a pathognomonic muscular deficiency. Antisynthetase syndrome is a subtype of IIM with an associated interstitial lung disease (ILD), characterized by pulmonary inflammation and fibrosis mediated by TGF-β. Pirfenidone is a new molecule with anti-inflammatory and anti-fibrotic properties, used for the treatment of idiopathic ILD, but has never been assessed in IIM.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the lesser-known effects of lupus on the intestines and liver, highlighting the importance of gut-liver interactions.
- Researchers conducted experiments on C57BL/6 mice with induced lupus, measuring fecal calprotectin levels and assessing various inflammatory and protein biomarkers over six weeks.
- Findings revealed an early increase in fecal calprotectin and significant liver inflammation, marking the activation of specific signaling pathways related to lupus progression.
Aims: Intensive care unit-acquired weakness (ICU-AW) is a complex spectrum of disability that delays recovery of critically ill-immobilized patients with sepsis. Much discrepancy remain on the use of corticosteroids and their impact on muscle regeneration in critical illness management. Therefore, the aim of this study is to investigate whether hydrocortisone (HCT) modulates muscle mass turnover in ICU-AW induced by sepsis with limb immobilization (SI).
View Article and Find Full Text PDFArticle Synopsis
- Inflammatory bowel disease (IBD) is a chronic condition linked to immune system issues, and disruptions in circadian rhythms can increase the risk of developing IBD.
- A study involving mice demonstrated that altered circadian rhythms exacerbated colitis symptoms and heightened inflammation, leading to serious gut damage.
- The presence of fecal calprotectin (FC) was found to correlate closely with the severity of colitis, suggesting it could be a valuable marker for assessing the impact of disrupted sleep patterns on IBD risk.
Article Synopsis
- Salt-sensitive hypertension increases the risk of chronic kidney disease through mechanisms involving inflammatory responses and fluid retention, particularly mediated by the protein TonEBP in macrophages.
- In a study with BALB/c mice, administration of VEGF-C demonstrated promising effects, including reduced kidney inflammation, decreased fibrosis, and improved kidney function in the context of high-salt-induced hypertension.
- VEGF-C not only lowered blood pressure but also enhanced protective kidney processes, suggesting it could be a potential therapeutic target for treating kidney damage in cases of salt-sensitive hypertension.
Aims: Cardiac fibroblasts (CFs) are emerging as major contributors to myocardial fibrosis (MF), a final common pathway of many etiologies of heart disease. Here, we studied the functional relevance of transient receptor potential canonical 3 (TRPC3) channels and nuclear factor of activated T cells c3 (NFATc3) signaling in rodent and human ventricular CFs, and whether their modulation would limit MF.
Results: A positive feedback loop between TRPC3 and NFATc3 drove a rat ventricular CF fibrotic phenotype.
Article Synopsis
- This study investigates how effective mifepristone is for helping rats regain weight after they were subjected to a low-calorie diet and treated with methylphenidate.
- The research involved 25 female rats, where some received only dietary restriction while others got both methylphenidate and mifepristone, revealing that mifepristone helped slightly increase weight compared to just methylphenidate.
- The findings suggest that mifepristone can potentially lower stress-related hormone responses and promote weight recovery, indicating it could be a useful option for treating anorexia nervosa in future research.
Introduction: Murine experimental models of antiphospholipid syndrome (eAPLS) showed neurologic dysfunction and therapeutic effect of the anticoagulant enoxaparin is well established. Omega-3 fatty acids and curcumin, tested in neuroinflammation and auto-immunity diseases, might be interesting therapeutic candidates. The aim of this study was to evaluate the effects of these candidates on neurologic severity in eAPLS.
View Article and Find Full Text PDFTransient receptor potential canonical (TRPC) Ca(2+)-permeant channels, especially TRPC3, are increasingly implicated in cardiorenal diseases. We studied the possible role of fibroblast TRPC3 in the development of renal fibrosis. In vitro, a macromolecular complex formed by TRPC1/TRPC3/TRPC6 existed in isolated cultured rat renal fibroblasts.
View Article and Find Full Text PDFBackground: The cellular mechanisms that regulate B-type natriuretic secretion are not well elicited. Intracellular fluctuation of calcium ions rate seems to be implicated.
Aims: In this study, we evaluate the role of ventricular transmembrane calcium channels in the secretion of BNP in normal adult rats (group N) and pressure overload hypertrophied ones (group H).