Influence of the insertion of a cationic peptide on the size and shape of nanoliposomes: a light scattering investigation.

Nanoliposomes are widely used for drug delivery in the human body. Cell-penetrating peptides are amphiphilic peptides inserting in the lipid bilayer of these lipid vesicles to induce the fusion with target cells. Separation by size exclusion chromatography coupled with the analysis by light scattering detectors provides both the hydrodynamic radius and the radius of gyration of all the liposomes in a sample.

Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes.

Cell cycle progression is dependent on the intracellular iron level, and chelators lead to iron depletion and decrease cell proliferation. This antiproliferative effect can be inhibited by exogenous iron. In this work, we present the synthesis of new synthetic calix[4]arene podands bearing alkyl acid and alkyl ester groups at the lower rim, designed as potential iron chelators.

Modulation of cell proliferation in rat liver cell cultures by new calix[4]arenes.

Cell cycle progression is dependent on intracellular iron level and chelators lead to iron depletion and decrease cell proliferation. This antiproliferative effect can be inhibited by exogenous iron. In this work, we present the synthesis of new synthetic calix[4]arene podands bearing two aspartic/glutamic acid, ornithine groups or hydrazide function at the lower rim, designed as potential iron chelators.