Publications by authors named "Viviana Parra Izquierdo"

Article Synopsis
  • The study aimed to find a link between fecal calprotectin (FC) levels and intestinal inflammation in patients with spondyloarthritis (SpA) who do not have inflammatory bowel disease.
  • Out of 180 SpA patients, approximately 27% exhibited positive fecal calprotectin and about 16% showed high levels, with significant associations found between higher FC levels and measures of disease activity and abdominal symptoms.
  • The results suggest that elevated FC levels, especially in patients showing loss of vascular pattern in the ileum, could serve as a useful biomarker for managing SpA, indicating a common immune response related to chronic inflammation.
View Article and Find Full Text PDF

Introduction: Endoscopy plays a fundamental role in inflammatory bowel disease (IBD), and becomes essential in diagnosis, treatment monitoring, and detection and management of complications.

Materials And Methods: The Pan American Crohn's and Colitis Organization (PANCCO) and the Inter-American Society of Endoscopy (SIED) appointed 22 Latin American experts in IBD to develop a consensus study using the modified Delphi method, based on the best available evidence. A working group of 22 members from 9 countries identified 15 topics and formulated 98 statements, who participated in 2 rounds of voting.

View Article and Find Full Text PDF

Biliary ileus is a mechanical intestinal obstruction characterized by symptoms such as abdominal pain, jaundice and fever. The treatment of choice in these cases is associated with a surgical approach according to the clinical condition of the patient. It is important to study this pathology since its timely diagnosis and treatment are essential to avoid serious complications associated with high morbidity and mortality.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates genetic factors linked to inflammatory bowel disease (IBD) in a Colombian population, revealing a complex interplay rather than a clear hereditary pattern.
  • The research involved 16 patients diagnosed with IBD after age 18, and findings showed a high prevalence of refractory cases and genetic variants associated with IBD risk among the group.
  • While specific genes were noted as potentially influential, the study concludes that these variants may contribute to IBD's pathophysiology without definitive proof of pathogenicity.
View Article and Find Full Text PDF

Objective: To compare the diversity and composition of the gastrointestinal microbiome of patients with SpA.

Methods: MiSeq sequencing of the V3-V4 region of the 16S ribosomal RNA gene was performed on DNA isolated from stool. Patients with concurrent SpA and IBD were excluded.

View Article and Find Full Text PDF

Objective: This study aimed to establish the association between HLA-A, B, DR genotypes and gastrointestinal variables in patients with SpA without inflammatory bowel disease (IBD).

Methods: Retrospective study of 91 patients with SpA and 401 healthy controls, with typing by Illumina Sequencing/PacBio and LIFECODES HLA-PCR/SSO multiplex sequencing technology. The presence of gastrointestinal symptoms was evaluated by administering a survey, and those who presented 2 or more symptoms were taken for clinical evaluation by rheumatology and gastroenterology, colonoscopy and histopathological study.

View Article and Find Full Text PDF
Article Synopsis
  • IBD is a chronic immune-related disease affecting the gastrointestinal tract, often starting in early adulthood, with rising incidence rates worldwide, particularly among women in Colombia.
  • Effective management is crucial as IBD is not curable, with the main goal being to achieve remission, especially before and during pregnancy to ensure the health of both mother and child.
  • Active IBD during conception and pregnancy can lead to negative outcomes, and specific complications like active perianal disease may necessitate cesarean delivery, increasing the risk of surgery and related complications.
View Article and Find Full Text PDF

Unlabelled: The presence of esophageal foreign body (EFB) is a common emergency in gastroenterology. The protocol for management and endoscopic intervention can be variable among institutions.

Objective: to define the clinical characteristics of EFB in adults, its radiological and endoscopic diagnosis, and complications based on a sample of patients in a gastroenterology center.

View Article and Find Full Text PDF

Introduction: There are no studies on efficacy of tofacitinib for moderate-severe ulcerative colitis (UC) in pediatric patients in Latin America. The aim of this study was to describe the efficacy and safety, in real world, treated with tofacitinib in our setting.

Materials And Methods: Case series of pediatric patients with UC who received treatment with tofacitinib in induction phase for 8 weeks and then maintenance therapy between November 2021 and February 2023.

View Article and Find Full Text PDF

Introduction: Tofacitinib is indicated in patients with moderate to severe ulcerative colitis (UC); however, given its rapid onset of action, it may constitute an alternative in patients with hospitalized severe acute UC. There are few data on this indication in the literature. The aim of this study was to describe the efficacy and safety of tofacitinib in the management of patients with hospitalized UC, as well as its clinical characteristics and other treatment patterns.

View Article and Find Full Text PDF

In Colombia there are no data about perception of quality of life (QoL) in inflammatory bowel disease (IBD). The aim of this study was to determine the perception of QoL by means of the IBDQ-32 questionnaire in patients with IBD from a sample of patients from different referral centers. We carried out a cross-sectional study in adults with IBD in clinical remission, in outpatient follow-up, in 3 institutions in different cities, between June 2022 and November 2022, eligible subjects were identified, information was collected on different dates, about socio-demographic and clinical aspects, and the IBDQ-32 questionnaire was evaluated on one occasion.

View Article and Find Full Text PDF

The study of the GI-tract microbiota of spondylarthritis (SpA) patients has focused on the analysis of feces samples, that picture mostly the luminal microbiota. The aim of this study was to determine the contribution of mucosal and luminal microbiome to the gut dysbiosis in SpA, using colonoscopy aspiration lavages (CAL), a recent alternative for regional studies of the GI-tract. We analyzed 59 CAL (from sigmoid colon and distal ileum), and 41 feces samples, from 32 SpA patients and 7 healthy individuals, using 16S rRNA gene-targeted metataxonomic profiling.

View Article and Find Full Text PDF

SpyGlass DS is a peroral cholangioscopy system, associated with improved image quality and configuration. Currently, there is diversity in its use and little information on its implementation, including clinical outcomes and adverse events. To describe the experience of using SpyGlass DS in several gastroenterology reference centres in Colombia, mentioning efficacy and possible adverse events.

View Article and Find Full Text PDF

Introduction: In Latin America and Colombia there are few studies about the clinical and therapeutic characteristics of patients with inflammatory bowel disease (IBD). The objective of this study is to obtain an approximation to these data from a sample of patients from different reference centres in Colombia.

Patients And Methods: Cross-sectional study in adult and paediatric patients, with IBD, attended ambulatory in 6 institutions in different cities, between 2017 and 2020 information was collected on different dates, about demographic, clinical, and therapeutic aspects.

View Article and Find Full Text PDF

Introduction: There are no studies on efficacy of tofacitinib for ulcerative colitis (UC) in Latin America. The aim of this study was to describe the efficacy and safety, in the real world, of patients with moderate-severe UC treated with tofacitinib in our setting.

Materials And Methods: Multicenter descriptive observational study, in patients with UC who received treatment with tofacitinib in induction phase for 8 weeks and then, maintenance therapy, between June 2019 and June 2022.

View Article and Find Full Text PDF
Article Synopsis
  • Spondyloarthritis (SpA) can lead to inflammatory bowel disease (IBD), with oral cavity changes often being the first clinical signs of IBD.
  • In a study with 80 SpA patients and 52 healthy controls, over 63% of the patients showed oral lesions, particularly gingivitis, which was significantly linked to IBD findings in the colon.
  • The research suggests that incorporating oral assessments into diagnostic processes for SpA could enhance early detection of IBD and improve patient care.
View Article and Find Full Text PDF

There is little literature on the implementation of screening criteria for inflammatory bowel disease (IBD) in patients with spondyloarthritis (SpA). This study aimed to apply IBD screening criteria in a group of patients with SpA without IBD diagnosis and correlate them to endoscopic findings and disease activity. A total of 82 patients with SpA were included.

View Article and Find Full Text PDF

Introduction: Perianal fistulizing Crohn's disease (CD) is a phenotype with a poor prognosis. There are no studies in our country. Our objective is to determine the clinical, sociodemographic and treatment characteristics of perianal fistulizing CD in a Colombian multicenter registry.

View Article and Find Full Text PDF

Background: Digital chromoendoscopy (Narrow Band Imaging By Olympus) or BLI (Blue Light Imaging By Fujifilm), with the magnification endoscope, allows a detailed evaluation of the mucosal surface and its vascular network, which facilitates the diagnosis and monitoring of early lesions. This technique has demonstrated a better detection, which allows optical diagnosis during a colonoscopy examination. Patients with SpA with nonspecific gastrointestinal symptoms, subclinical intestinal inflammation are defined as endoscopic and histologically.

View Article and Find Full Text PDF

Background: The Spondyloarthritis (SpA) is a group of chronic inflammatory rheumatic diseases, in which 5-10% of extra-articular manifestations are gastrointestinal such as the inflammatory bowel disease. Objective: To apply the clinical criteria for the screening of inflammatory bowel disease (IBD) in patients with SpA with gastrointestinal symptoms and its association with disease activity and function.

Methods: A Cross-sectional study included 82 patients with SpA, according to ASAS classification criteria without diagnosis of IBD.

View Article and Find Full Text PDF
Article Synopsis
  • Tofacitinib, an FDA-approved drug in Colombia for treating ulcerative colitis (UC), inhibits Janus kinases involved in the disease's development.
  • A case series involving six Colombian patients with moderate to severe UC revealed varying responses to treatment over an induction and maintenance phase, highlighting both clinical and paraclinical evaluations.
  • Out of the six patients, most showed remission or improvement in symptoms, with some avoiding colectomy, while one patient did not respond to treatment at all.
View Article and Find Full Text PDF

Background: Spondyloarthritis (SpA) is a heterogeneous group of chronic autoinflammatory disorders that can present extra-articular gastrointestinal manifestations. Among them is mainly inflammatory bowel disease (IBD). Although IBD mainly affects the intestinal tract, it can include early manifestations evident in the oral cavity.

View Article and Find Full Text PDF
Article Synopsis
  • - The text discusses a rare case of metastatic Crohn's disease (MCD) presenting with severe oral and vulvar lesions, leading to the extraction of numerous teeth and significant discomfort, without gastrointestinal symptoms.
  • - The patient, who has a family history of autoimmune conditions, exhibited symptoms like severe gingivitis, ulcers, and lip edema, prompting initial considerations for Behçet's disease but ultimately diagnosed with MCD after negative tests for other conditions.
  • - Management included topical steroids for skin lesions and dental implants for oral issues, along with the introduction of anti-TNF treatment Adalimumab, which led to the development of paradoxical psoriasis as a side effect.
View Article and Find Full Text PDF

Achalasia in pregnancy is an infrequent, poorly understood condition and its treatment is not clearly defined. The repercussions on the patients nutritional status are serious and in a pregnant woman have serious implications for the course of gestation, with high risk of intrauterine growth restriction, preterm delivery and even fetal loss; there are symptoms that can be confused with hyperemesis gravidarum delaying the diagnosis. The therapeutic options are medical treatment, endoscopic and surgical interventions; to decide what is the best treatment, we should be taken into account the severity, gestational age and patient conditions.

View Article and Find Full Text PDF

Background: Antibodies against neutrophil cytoplasm (ANCA) are associated with vasculitis. There are different methods to determine their presence. The interference of antinuclear antibodies (ANA) in the differentiation between P-ANCA and C-ANCA patterns has been described.

View Article and Find Full Text PDF